Douville Julie, David Jocelyn, Lemieux Karine M, Gaudreau Luc, Ramotar Dindial
Département de Biologie, Université de Sherbrooke, Quebec, Canada.
Genetics. 2006 Feb;172(2):1369-72. doi: 10.1534/genetics.105.046110. Epub 2005 Dec 1.
We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.
我们发现,缺乏磷酸酶激活剂Rrd1或磷酸酶Pph3的突变体对雷帕霉素具有抗性,并且双突变体表现出协同反应。这种表型可能与突变体无法降解RNA聚合酶II有关,从而导致维持生长的关键基因转录。