Zieliński J, Chodosowska E
Respiration. 1977;34(1):31-5. doi: 10.1159/000193773.
14 asthmatic patients developing regularly exercise-induced bronchoconstriction were subjected to a submaximal exercise on a bicycle ergometer. On the first day the exercise was not preceded by any medication; on the second, 50 mg thiazinamium was given, and on the third day 2 mg atropine was given before the exercise. The changes in the calibre of the bronchi were assessed with a Wright peak flow meter. With thiazinamium a complete protection against the bronchoconstriction was observed in 12 patients, in one the protection was partial and in an other no beneficial effect of the drug was found. It seems that protection given by thiazinamium was due to its antihistaminic property and not to the anticholinergic one, as among 10 patients protected by thiazinamium, only 2 were also protected by the atropine.
14名经常发生运动诱发性支气管收缩的哮喘患者在自行车测力计上进行了次极量运动。第一天运动前未服用任何药物；第二天服用50毫克噻嗪铵，第三天运动前服用2毫克阿托品。用赖特峰值流量计评估支气管口径的变化。使用噻嗪铵后，12名患者的支气管收缩得到了完全预防，1名患者得到了部分预防，另1名患者未发现该药物有有益作用。噻嗪铵的预防作用似乎是由于其抗组胺特性，而非抗胆碱能特性，因为在10名受噻嗪铵保护的患者中，只有2名也受到阿托品的保护。
