Kiviloog J
Pediatrics. 1975 Nov;56(5 pt-2 suppl):940-1.
Because asthmatics who exhibit exercise-induced bronchonconstriction are also known to be sensitive to the cholinergic drug methacholine, an attempt was made in this study to block exercise-induced bronchoconstriction in nine asthmatics with a known history of exercise-induced bronchoconstriction by pretreatment with atropine. Inhalation of atropine before exercise produced milder exercise-induced bronchoconstriction in three of the nine asthmatics and a total inhibition of exercise-induced bronchoconstriction in two patients. The remaining four asthmatics still exhibited bronchoconstriction during exercise, despite pretreatment with atropine. There was no correlation between a past history of reagenic bronchial allergy or aspirin hypersensitivity and the extent of atropine inhibition of exercise-induced bronchoconstriction. This varied effect of atropine was considered to be due in part to varying amounts of the drug reaching those parts of the bronchial tres most involved in triggering exercise-induced bronchoconstriction.
由于已知表现出运动诱发性支气管收缩的哮喘患者对胆碱能药物乙酰甲胆碱也敏感，本研究尝试通过用阿托品预处理来阻断9名有运动诱发性支气管收缩病史的哮喘患者的运动诱发性支气管收缩。在运动前吸入阿托品，9名哮喘患者中有3名运动诱发性支气管收缩较轻，2名患者运动诱发性支气管收缩被完全抑制。其余4名哮喘患者尽管用阿托品预处理，运动期间仍表现出支气管收缩。既往变应性支气管过敏或阿司匹林超敏反应病史与阿托品对运动诱发性支气管收缩的抑制程度之间无相关性。阿托品的这种不同效果被认为部分是由于到达支气管树中最参与引发运动诱发性支气管收缩部位的药物量不同。
