口服西卡前列素对高胆固醇血症兔的抗动脉粥样硬化特性

Antiatherosclerotic properties of oral cicaprost in hypercholesterolemic rabbits.

作者信息

Braun M, Sarbia M, Kienbaum P, Hohlfeld T, Weber A, Schrör K

机构信息

Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, FRG.

出版信息

Agents Actions Suppl. 1992;37:282-8. doi: 10.1007/978-3-0348-7262-1_39.

DOI:10.1007/978-3-0348-7262-1_39

PMID:1632302

Abstract

The effects of the orally active prostacyclin mimetic cicaprost on morphologic and functional alterations of rabbit aorta was investigated in experimental hypercholesterolemia. Oral cicaprost resulted in a significantly reduced aortic atheromatous plaque formation and partially prevented hypercholesterolemia-induced impairment of endothelium-dependent relaxations. It is concluded that long-term substitution with PGI2 may beneficially influence the progression of atherosclerosis.

摘要

在实验性高胆固醇血症中，研究了口服活性前列环素类似物西卡前列素对兔主动脉形态和功能改变的影响。口服西卡前列素可显著减少主动脉粥样斑块形成，并部分预防高胆固醇血症诱导的内皮依赖性舒张功能受损。得出的结论是，长期用前列环素替代可能对动脉粥样硬化的进展产生有益影响。