Woditsch I, Hohlfeld T, Strobach H, Schrör K
Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, FRG.
Agents Actions Suppl. 1992;37:297-304. doi: 10.1007/978-3-0348-7262-1_41.
Isolated Langendorff-hearts prepared from cholesterol fed rabbits (1% cholesterol for 3 months) showed a significant impairment in endothelium-dependent relaxation after short-term infusion of bradykinin (0.05 mumol/l) and carbamoylcholine (0.1 mumol/l). Generation of the endothelial mediators nitric oxide and prostacyclin by bradykinin was enhanced in hypercholesterolemia. Cicaprost treatment (5 micrograms/kg x d) largely prevented the hypercholesterolemia-related impairment of coronary vasodilation and nitric oxide release. It is concluded that (i) impairment of endothelium-dependent relaxation in the coronary microcirculation of hypercholesterolemic rabbits is not due to diminished endothelium-dependent mediator release but rather to accelerated inactivation or reduced activity of the released mediators and that (ii) oral cicaprost beneficially influence these alterations.
从喂食胆固醇的兔子（1%胆固醇，持续3个月）制备的离体Langendorff心脏，在短期输注缓激肽（0.05 μmol/L）和卡巴胆碱（0.1 μmol/L）后，内皮依赖性舒张功能出现显著受损。在高胆固醇血症中，缓激肽生成内皮介质一氧化氮和前列环素的过程增强。西卡前列素治疗（5微克/千克×天）在很大程度上预防了与高胆固醇血症相关的冠状动脉舒张功能障碍和一氧化氮释放减少。结论是：（i）高胆固醇血症兔子冠状动脉微循环中内皮依赖性舒张功能受损并非由于内皮依赖性介质释放减少，而是由于释放的介质失活加速或活性降低；（ii）口服西卡前列素对这些改变有有益影响。
