Schwandt Melanie L, Cullins Eva, Ramchandani Vijay A
Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Human Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Neurobiol Stress. 2024 May 16;31:100644. doi: 10.1016/j.ynstr.2024.100644. eCollection 2024 Jul.
Stress plays a well-documented role in alcohol consumption and the risk for developing alcohol use disorder. The concept of resilience - coping with and successfully adapting to stressful life experiences - has received increasing attention in the field of addiction research in recent decades, and there has been an accumulation of evidence for resilience as a protective factor against problematic alcohol consumption, risk for alcohol use disorder, disorder severity, and relapse. The conceptual and methodological approaches used in the generation of this evidence vary considerably across investigations, however. In light of this, we carried out this review in order to provide a more thorough understanding of the meaning and scope of resilience, what factors contribute to resilience, how it is measured, and how it relates to alcohol-associated phenotypes. Implications for treatment through the use of resilience-building interventions are likewise discussed, as well as implications for future research on the role of resilience in the etiology and clinical outcomes of alcohol use disorder.
压力在饮酒及酒精使用障碍的发生风险中所起的作用已有充分记录。复原力的概念——应对并成功适应压力性生活经历——在近几十年来的成瘾研究领域受到了越来越多的关注,并且有越来越多的证据表明,复原力是预防酒精消费问题、酒精使用障碍风险、障碍严重程度及复发的保护因素。然而,在生成这些证据时所采用的概念和方法在不同研究中差异很大。有鉴于此,我们开展了本综述,以便更全面地理解复原力的含义和范围、促成复原力的因素、其测量方法以及它与酒精相关表型的关系。同样也讨论了通过使用增强复原力的干预措施进行治疗的意义,以及复原力在酒精使用障碍的病因学和临床结果中的作用的未来研究意义。