Pece A, Sannace C, Menchini U, Virgili G, Galli L, Isola V, Brancato R
Department of Ophthalmology, Hospital of Melegnano, Predabissi (MI), Italy.
Eur J Ophthalmol. 2005 Nov-Dec;15(6):759-63.
To assess whether fluorescein angiography (FA) alone without indocyanine green angiography (ICGA) can identify and localize occult choroidal neovascularization (CNV) in age-related macular degeneration (ARMD).
Seventy-nine eyes of 77 consecutive patients with occult CNV were evaluated independently by two skilled physicians at first with FA alone and then with FA combined with ICGA by fundus camera.
The agreement between FA and ICGA was 73% and 68% for the two physicians (K=0.585 and 0.512, respectively). The first operator correctly identified 20/27 as plaque CNV; six had different sizes and locations. The second operator identified 25/30, with one mistaken for size and location. For focal CNV the first operator identified 34/39, and the second one 23/35.
Comparing the FA results with ICGA, CNV was correctly identified in about 60% of cases. Therefore, ICGA should be considered an indispensable diagnostic test to identify the presence, the type, and the location of occult CNV.
评估仅使用荧光素血管造影（FA）而不使用吲哚菁绿血管造影（ICGA）是否能够识别和定位年龄相关性黄斑变性（ARMD）中的隐匿性脉络膜新生血管（CNV）。
77例连续患有隐匿性CNV的患者的79只眼睛，首先由两名技术熟练的医生单独使用FA进行评估，然后通过眼底相机使用FA联合ICGA进行评估。
两位医生中，FA与ICGA之间的一致性分别为73%和68%（K值分别为0.585和0.512）。第一位检查者正确识别出20/27为斑块状CNV；其中6只眼睛的大小和位置不同。第二位检查者识别出25/30，但有1只眼睛的大小和位置有误。对于局灶性CNV，第一位检查者识别出34/39，第二位检查者识别出23/35。
将FA结果与ICGA进行比较，约60% 的病例中CNV得到了正确识别。因此，ICGA应被视为识别隐匿性CNV的存在、类型和位置不可或缺的诊断检查。
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