年龄相关性黄斑变性继发地图样萎缩研究的临床终点
CLINICAL ENDPOINTS FOR THE STUDY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION.
作者信息
Sadda SriniVas R, Chakravarthy Usha, Birch David G, Staurenghi Giovanni, Henry Erin C, Brittain Christopher
机构信息
*Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California; †David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California; ‡Centre for Experimental Medicine, Queen's University of Belfast, Belfast, United Kingdom; §Retina Foundation of the Southwest, Dallas, Texas; ¶Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas; **Department of Biomedical and Clinical Science "Luigi Sacco," Sacco Hospital, University of Milan, Milan, Italy; ††Genentech, Inc., South San Francisco, California; and ‡‡F. Hoffmann-La Roche Ltd., Basel, Switzerland.
出版信息
Retina. 2016 Oct;36(10):1806-22. doi: 10.1097/IAE.0000000000001283.
PURPOSE
To summarize the recent literature describing the application of modern technologies in the study of patients with geographic atrophy (GA) secondary to age-related macular degeneration.
METHODS
Review of the literature describing the terms and definitions used to describe GA, imaging modalities used to capture and measure GA, and the tests of visual function and functional deficits that occur in patients with GA.
RESULTS
In this paper, we describe the evolution of the definitions used to describe GA. We compare imaging modalities used in the characterization of GA, report on the sensitivity and specificity of the techniques where data exist, and describe the correlations between these various modes of capturing the presence of GA. We review the functional tests that have been used in patients with GA, and critically examine their ability to detect and quantify visual deficits.
CONCLUSION
Ophthalmologists and retina specialists now have a wide range of assessments available for the functional and anatomic characterization of GA in patients with age-related macular degeneration. To date, studies have been limited by their unimodal approach, and we recommend that future studies of GA use multimodal imaging. We also suggest strategies for the optimal functional testing of patients with GA.
目的
总结近期描述现代技术在年龄相关性黄斑变性继发地图样萎缩（GA）患者研究中的应用的文献。
方法
回顾描述GA的术语和定义、用于捕捉和测量GA的成像方式，以及GA患者发生的视觉功能和功能缺陷测试的文献。
结果
在本文中，我们描述了用于描述GA的定义的演变。我们比较了用于GA特征描述的成像方式，在有数据的情况下报告技术的敏感性和特异性，并描述这些捕捉GA存在的不同模式之间的相关性。我们回顾了已用于GA患者的功能测试，并严格审查其检测和量化视觉缺陷的能力。
结论
眼科医生和视网膜专家现在有多种评估方法可用于年龄相关性黄斑变性患者GA的功能和解剖特征描述。迄今为止，研究受到单峰方法的限制，我们建议未来GA的研究采用多模态成像。我们还提出了GA患者最佳功能测试的策略。
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