一名接受干扰素和利巴韦林治疗的丙型肝炎患者发生视网膜分支动脉阻塞合并视网膜分支静脉阻塞。
Branch retinal artery occlusion combined with branch retinal vein occlusion in a patient with hepatitis C treated with interferon and ribavirin.
作者信息
Nicolò M, Artioli S, La Mattina G C, Ghiglione D, Calabria G
机构信息
Department of Neuroscience, Ophthalmology and Genetic, University Eye Clinic of Genova, Genova, Italy.
出版信息
Eur J Ophthalmol. 2005 Nov-Dec;15(6):811-4.
PURPOSE
To report a case of a combined branch retinal artery and vein occlusion in a patient with hepatitis C treated with interferon and ribavirin.
METHODS
A 29-year-old man with a 1-week history of sudden visual field defect and decrease of central visual acuity was examined.
RESULTS
Ophthalmoscopy and fluorescein angiography demonstrated an ischemic whitening of the inferior hemi-retina involving part of the macular region, numerous intraretinal hemorrhages, and a significant delay in arterial and vein filling of the dye.
CONCLUSIONS
The findings of a retinopathy associated with interferon and ribavirin treatment of hepatitis C are important. The symptomatic permanent visual field defect and decrease of central visual acuity developing following a branch retinal artery and vein occlusion event emphasizes the need for careful and regular ocular monitoring of patients receiving interferon for hepatitis C.
目的
报告1例丙型肝炎患者在接受干扰素和利巴韦林治疗时发生视网膜动脉和静脉联合分支阻塞的病例。
方法
对一名有1周突然视野缺损和中心视力下降病史的29岁男性进行了检查。
结果
检眼镜检查和荧光素血管造影显示，视网膜下半部包括部分黄斑区出现缺血性变白，视网膜内有大量出血，染料在动脉和静脉充盈时明显延迟。
结论
丙型肝炎患者接受干扰素和利巴韦林治疗时出现视网膜病变的发现很重要。视网膜动脉和静脉分支阻塞事件后出现的有症状的永久性视野缺损和中心视力下降强调了对接受干扰素治疗丙型肝炎的患者进行仔细和定期眼部监测的必要性。
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