Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado Denver School of Medicine and the Children's Hospital, Aurora, CO 80045, USA.
J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):183-6. doi: 10.1097/MPG.0b013e3181b99cf0.
Interferon treatment for chronic viral hepatitis C (HCV) has been associated with the development of retinopathy in 19% to 29% of adults. Our purpose is to describe the ophthalmologic complications of pegylated interferon-alpha2a with either placebo or ribavirin in children with chronic HCV (the PEDS-C trial).
Prospective, comprehensive ophthalmologic examinations including slit lamp at enrollment and after 24 and 48 weeks of treatment of 114 children participating in a randomized clinical trial.
One hundred and twenty-eight children were screened for entry, of whom 123 had an eye examination and no child had existing retinal disease. One hundred fourteen children were eligible and were treated. One hundred ten children had an eye examination at 24 weeks and 103 children at 48 weeks. Three of 114 subjects (2.6%) developed documented (n = 2) or possible (1) serious eye complications. One subject developed evidence of ischemic retinopathy (cotton-wool spots) by week 24, 1 developed uveitis by week 48, and 1 reported at week 48 transient (<4 hours) monocular blindness that had occurred at week 36 with a subsequent normal examination at week 48.
Ophthalmologic complications are infrequent in children who are treated with pegylated interferon-alpha2a for HCV (2%-3%). Because of the potential severity of ischemic retinopathy and uveitis, prospective ocular assessment should remain part of the monitoring strategy for children who are treated with interferon for HCV.
干扰素治疗慢性丙型肝炎病毒（HCV）可导致 19%至 29%的成年人发生视网膜病变。我们的目的是描述聚乙二醇干扰素-α2a 联合安慰剂或利巴韦林治疗慢性丙型肝炎儿童（PEDS-C 试验）的眼科并发症。
前瞻性、全面的眼科检查，包括纳入时和治疗 24 周和 48 周后的裂隙灯检查，共纳入 114 名参与随机临床试验的儿童。
128 名儿童接受了入组筛选，其中 123 名进行了眼部检查，无儿童存在视网膜疾病。114 名儿童符合条件并接受了治疗。100 名儿童在 24 周时和 103 名儿童在 48 周时进行了眼部检查。114 名受试者中有 3 名（2.6%）发生了有记录（n=2）或可能（1）的严重眼部并发症。1 名受试者在第 24 周出现缺血性视网膜病变（棉絮斑）的证据，1 名在第 48 周出现葡萄膜炎，1 名在第 48 周报告短暂（<4 小时）单眼失明，发生在第 36 周，随后在第 48 周检查正常。
用聚乙二醇干扰素-α2a 治疗 HCV 的儿童眼科并发症罕见（2%-3%）。由于缺血性视网膜病变和葡萄膜炎的潜在严重程度，前瞻性眼部评估应仍然是干扰素治疗 HCV 儿童监测策略的一部分。
