阿比西诺酮II及相关化合物作为潜在化学预防剂的合成。

Synthesis of Abyssinone II and related compounds as potential chemopreventive agents.

作者信息

Moriarty Robert M, Grubjesic Simonida, Surve Bhushan C, Chandersekera Susantha N, Prakash Om, Naithani Rajesh

机构信息

Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.

出版信息

Eur J Med Chem. 2006 Feb;41(2):263-7. doi: 10.1016/j.ejmech.2005.09.008. Epub 2005 Dec 2.

DOI:10.1016/j.ejmech.2005.09.008

PMID:16330130

Abstract

A facile and efficient approach to the synthesis of prenylated flavonoids as potential chemopreventive agents has been described. This features the synthesis of prenyl halide, prenylation of p-hydroxybenzaldehyde, formation of prenylated polyhydroxychalcone and cyclization of prenylated polyhydroxychalcone to flavanones (15) and (16), and flavonol (17) starting from isoprene (1). The structures of all three compounds have been characterized by NMR, IR and mass spectroscopy.

摘要

本文描述了一种简便有效的合成异戊烯基黄酮类化合物的方法，该类化合物具有潜在的化学预防作用。此方法包括从异戊二烯（1）开始合成卤代异戊烯、对羟基苯甲醛的异戊烯基化、形成异戊烯基化的多羟基查耳酮以及将异戊烯基化的多羟基查耳酮环化生成黄烷酮（15）和（16）以及黄酮醇（17）。所有三种化合物的结构均通过核磁共振、红外光谱和质谱进行了表征。