• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara.来自具翅缘菖蒲的二氢异香豆素对芳香酶的选择性抑制作用。
J Nat Prod. 2008 Jun;71(6):1082-4. doi: 10.1021/np800098f. Epub 2008 May 8.
2
Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.从内生真菌 Colletotrichum sp. 中分离得到的异香豆素和邻苯二甲酸内酯的自由基清除和抗氧化活性
J Nat Prod. 2011 Jan 28;74(1):79-81. doi: 10.1021/np1003752. Epub 2010 Dec 21.
3
Dihydroisocoumarin from Xyris pterygoblephara active against dermatophyte fungi.来自具翅缘毛黄眼草的二氢异香豆素对皮肤癣菌具有活性。
Phytochemistry. 2008 Jan;69(2):439-44. doi: 10.1016/j.phytochem.2007.08.002. Epub 2007 Sep 17.
4
Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis.云南红豆杉木材中细胞色素 P450 3A4 的抑制成分。
J Nat Prod. 2011 Jan 28;74(1):102-5. doi: 10.1021/np100665j. Epub 2010 Dec 7.
5
Cytotoxic and Anti-Inflammatory Activities of Dihydroisocoumarin and Xanthone Derivatives from .二氢异香豆素和黄烷酮衍生物的细胞毒性和抗炎活性研究。
Molecules. 2021 Nov 1;26(21):6626. doi: 10.3390/molecules26216626.
6
Anti-tumor effect of Shu-Gan-Liang-Xue decoction in breast cancer is related to the inhibition of aromatase and steroid sulfatase expression.疏肝凉血汤对乳腺癌的抗肿瘤作用与抑制芳香化酶和类固醇硫酸酯酶表达有关。
J Ethnopharmacol. 2014 Jul 3;154(3):687-95. doi: 10.1016/j.jep.2014.04.045. Epub 2014 May 6.
7
Antiproliferative metabolites from the Northern African endemic plant Daucus virgatus (Apiaceae).来自北非特有植物野胡萝卜（伞形科）的抗增殖代谢产物。
Phytochemistry. 2017 Nov;143:194-198. doi: 10.1016/j.phytochem.2017.08.010. Epub 2017 Aug 23.
8
Evaluation of Brazilian plants on cancer chemoprevention targets in vitro.巴西植物对体外癌症化学预防靶点的评价。
Phytother Res. 2010 Jun;24(6):928-33. doi: 10.1002/ptr.3050.
9
Synthesis, antiproliferative activities, and computational evaluation of novel isocoumarin and 3,4-dihydroisocoumarin derivatives.新型异香豆素和 3,4-二氢异香豆素衍生物的合成、抗增殖活性及计算评价。
Eur J Med Chem. 2016 Mar 23;111:103-13. doi: 10.1016/j.ejmech.2016.01.051. Epub 2016 Jan 30.
10
HPLC-based activity profiling for GABA(A) receptor modulators: a new dihydroisocoumarin from Haloxylon scoparium.基于 HPLC 的 GABA(A) 受体调节剂活性分析：来自沙冬青的一种新的二氢异香豆素。
J Nat Prod. 2010 Apr 23;73(4):768-70. doi: 10.1021/np900803w.

引用本文的文献

1
()-1-(3-(3-Hydroxy-4-Methoxyphenyl)-1-(3,4,5-Trimethoxyphenyl)allyl)-1-1,2,4-Triazole and Related Compounds: Their Synthesis and Biological Evaluation as Novel Antimitotic Agents Targeting Breast Cancer.（）-1-（3-（3-羟基-4-甲氧基苯基）-1-（3,4,5-三甲氧基苯基）烯丙基）-1H-1,2,4-三唑及相关化合物：它们作为靶向乳腺癌的新型抗有丝分裂剂的合成与生物学评价
Pharmaceuticals (Basel). 2025 Jan 17;18(1):118. doi: 10.3390/ph18010118.
2
Dinuclear Zn-Catalytic System as Brønsted Base and Lewis Acid for Enantioselectivity in Same Chiral Environment.双核锌催化体系作为布朗斯特碱和路易斯酸在同一手性环境中实现对映选择性
ACS Omega. 2024 Feb 5;9(6):6074-6092. doi: 10.1021/acsomega.3c07446. eCollection 2024 Feb 13.
3
Dihydroisocoumarins, Naphthalenes, and Further Polyketides from and : Isolation, Identification and Their 5-LOX/COX-1 Inhibiting Potency.二氢异香豆素、萘和进一步的多酮类化合物来自 和 ：分离、鉴定及其 5-脂氧合酶/环氧化酶-1 抑制活性。
Molecules. 2021 Jul 12;26(14):4223. doi: 10.3390/molecules26144223.
4
Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1-1,2,4-triazoles and 1-(Diarylmethyl)-1-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer.新型抗有丝分裂剂1-(二芳基甲基)-1H-1,2,4-三唑类化合物和1-(二芳基甲基)-1H-咪唑类化合物的合成及其对乳腺癌活性的生物学评价
Pharmaceuticals (Basel). 2021 Feb 22;14(2):169. doi: 10.3390/ph14020169.
5
Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5.新型3,4-二氢异香豆素抑制多药耐药肿瘤中的人P-糖蛋白和乳腺癌耐药蛋白，并对酵母Pdr5表现出底物抑制作用。
Front Pharmacol. 2019 Apr 16;10:400. doi: 10.3389/fphar.2019.00400. eCollection 2019.
6
Uncovering the Mechanisms of Chinese Herbal Medicine (MaZiRenWan) for Functional Constipation by Focused Network Pharmacology Approach.基于聚焦网络药理学方法揭示中药（麻子仁丸）治疗功能性便秘的作用机制
Front Pharmacol. 2018 Mar 26;9:270. doi: 10.3389/fphar.2018.00270. eCollection 2018.
7
Synthesis of isocoumarins with different substituted patterns via Passerini-aldol sequence.通过Passerini-羟醛反应序列合成具有不同取代模式的异香豆素。
Org Lett. 2014 Sep 5;16(17):4504-7. doi: 10.1021/ol502048e. Epub 2014 Aug 20.
8
Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.新型芳香酶抑制剂的研制：3-苯基色满-4-酮（异黄酮）衍生物的设计、合成及抑制活性。
Bioorg Med Chem. 2012 Apr 15;20(8):2603-13. doi: 10.1016/j.bmc.2012.02.042. Epub 2012 Feb 27.
9
Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz.从白术中筛选具有芳香酶抑制活性的化合物
Molecules. 2011 Apr 14;16(4):3146-51. doi: 10.3390/molecules16043146.
10
Natural compounds with aromatase inhibitory activity: an update.具有芳香酶抑制活性的天然化合物：最新研究进展。
Planta Med. 2010 Aug;76(11):1087-93. doi: 10.1055/s-0030-1250169. Epub 2010 Jul 15.

本文引用的文献

1
Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/pi interaction.聚焦于CH/π相互作用的蛋白激酶C同工酶新型荧光配体的设计与理化性质
Bioorg Med Chem. 2008 Jan 15;16(2):650-7. doi: 10.1016/j.bmc.2007.10.045. Epub 2007 Oct 22.
2
Insights on adjuvant endocrine therapy for premenopausal and postmenopausal breast cancer.绝经前和绝经后乳腺癌辅助内分泌治疗的见解
Expert Rev Anticancer Ther. 2007 Sep;7(9):1243-53. doi: 10.1586/14737140.7.9.1243.
3
Dihydroisocoumarin from Xyris pterygoblephara active against dermatophyte fungi.来自具翅缘毛黄眼草的二氢异香豆素对皮肤癣菌具有活性。
Phytochemistry. 2008 Jan;69(2):439-44. doi: 10.1016/j.phytochem.2007.08.002. Epub 2007 Sep 17.
4
Reducing the risk of distant metastases in breast cancer patients: role of aromatase inhibitors.降低乳腺癌患者远处转移风险：芳香化酶抑制剂的作用
Cancer Treat Rev. 2007 Dec;33(8):681-7. doi: 10.1016/j.ctrv.2007.07.014. Epub 2007 Sep 11.
5
Developing a high-throughput system for the screening of cytochrome P450 1A1--inhibitory polyphenols.开发一种用于筛选细胞色素P450 1A1抑制性多酚的高通量系统。
Toxicol In Vitro. 2007 Sep;21(6):996-1002. doi: 10.1016/j.tiv.2007.04.005. Epub 2007 Apr 27.
6
Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer.（±）-阿比西酮II及其类似物作为芳香化酶抑制剂用于乳腺癌化学预防的合成与生物学评价
J Med Chem. 2007 Jun 14;50(12):2799-806. doi: 10.1021/jm070109i. Epub 2007 May 19.
7
(Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture.植物化学物质对人原代乳腺成纤维细胞、MCF-7细胞及其共培养物的（抗）雌激素作用。
Toxicol Appl Pharmacol. 2007 Jun 15;221(3):372-83. doi: 10.1016/j.taap.2007.03.016. Epub 2007 Mar 27.
8
Three-dimensional model of the human aromatase enzyme and density functional parameterization of the iron-containing protoporphyrin IX for a molecular dynamics study of heme-cysteinato cytochromes.人芳香酶的三维模型以及含铁原卟啉IX的密度泛函参数化，用于血红素-半胱氨酸细胞色素的分子动力学研究。
Proteins. 2006 Mar 1;62(4):1074-87. doi: 10.1002/prot.20829.
9
Synthesis of Abyssinone II and related compounds as potential chemopreventive agents.阿比西诺酮II及相关化合物作为潜在化学预防剂的合成。
Eur J Med Chem. 2006 Feb;41(2):263-7. doi: 10.1016/j.ejmech.2005.09.008. Epub 2005 Dec 2.
10
Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort.圣约翰草中的黄酮类化合物对人细胞色素CYP 1酶的抑制作用。
Toxicology. 2006 Jan 16;217(2-3):194-205. doi: 10.1016/j.tox.2005.09.010. Epub 2005 Nov 4.

来自具翅缘菖蒲的二氢异香豆素对芳香酶的选择性抑制作用。

Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara.

作者信息

Endringer Denise C, Guimarães Keller G, Kondratyuk Tamara P, Pezzuto John M, Braga Fernão C

机构信息

Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, 6627, CEP 31270-901, Belo Horizonte, Brazil.

出版信息

J Nat Prod. 2008 Jun;71(6):1082-4. doi: 10.1021/np800098f. Epub 2008 May 8.

DOI:10.1021/np800098f
PMID:18462007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2562161/
Abstract

Aromatase is a well-established target for the chemoprevention of breast cancer. The dihydroisocoumarin (3 R,4 R)-(-)-6-methoxy-1-oxo-3-pentyl-3,4-dihydro-1 H-isochromen-4-yl acetate (1) (IC 50 = 1.6 +/- 0.1 microM), isolated from aerial parts of Xyris pterygoblephara, showed aromatase inhibitory activity. The specificity of 1 was evaluated by inhibition assays with cytochrome P450 enzymes. CYP1A1 was inhibited modestly (IC 50 = 38.0 +/- 2.0 microM), while CYP2C8 and CYP3A4 enzymes were not affected. Dihydroisocoumarin 1 showed weak antiproliferative activity against MCF-7 (IC 50 = 66.9 +/- 2.3 microM) and LNCaP (IC 50 = 57.5 +/- 2.0 microM) cells and was inactive against LU-1 and HepG2 cells in culture. These results demonstrate the potential of dihydroisocoumarin 1 to serve as a selective aromatase inhibitor.

摘要

芳香化酶是乳腺癌化学预防中一个已确立的靶点。从翼萼黄眼草地上部分分离得到的二氢异香豆素(3R,4R)-(-)-6-甲氧基-1-氧代-3-戊基-3,4-二氢-1H-异色烯-4-基乙酸酯(1)(IC50 = 1.6±0.1μM)具有芳香化酶抑制活性。通过细胞色素P450酶抑制试验评估了化合物1的特异性。CYP1A1受到适度抑制(IC50 = 38.0±2.0μM)，而CYP2C8和CYP3A4酶未受影响。二氢异香豆素1对MCF-7(IC50 = 66.9±2.3μM)和LNCaP(IC50 = 57.5±2.0μM)细胞显示出较弱的抗增殖活性，对培养中的LU-1和HepG2细胞无活性。这些结果证明了二氢异香豆素1作为选择性芳香化酶抑制剂的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3095/2562161/b3a5c44195a9/nihms67693f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3095/2562161/665480b6fab6/nihms67693f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3095/2562161/b3a5c44195a9/nihms67693f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3095/2562161/665480b6fab6/nihms67693f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3095/2562161/b3a5c44195a9/nihms67693f2.jpg