Horák D, Svec F, Adamyan A, Titova M, Skuba N, Voronkova O, Trostenyuk N, Vishnevskii V, Gumargalieva K
Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague.
Biomaterials. 1992;13(8):521-6. doi: 10.1016/0142-9612(92)90103-u.
A haemostatic material suitable for embolization was prepared by the adsorption of haemostatics--ethamsylate and aminocaproic acid in the spherical particles of porous poly(2-hydroxyethyl methacrylate) (p(HEMA)). The degree of purification of ethamsylate-treated particles was tested by an analysis of donor blood in contact with the material. An evaluation of the haemostatic properties of these materials was obtained by the determination of the indicators of blood clotting: activated partial thromboplastin time, thrombin time, and prothrombin time. Ethamsylate or aminocaproic acid-containing p(HEMA) has a distinct haemostatic effect on pathological blood of patients suffering from focal alterations of the liver. These haemostatic emboli materials show promise for the immediate control of various haemorrhages; when introduced into a zone with increased haemorrhage, they may help to correct disturbed haemostasis.
通过将止血剂（酚磺乙胺和氨基己酸）吸附在多孔聚甲基丙烯酸2-羟乙酯（p(HEMA)）球形颗粒中制备了一种适用于栓塞的止血材料。通过分析与该材料接触的供血者血液来测试经酚磺乙胺处理颗粒的纯化程度。通过测定凝血指标（活化部分凝血活酶时间、凝血酶时间和凝血酶原时间）来评估这些材料的止血性能。含酚磺乙胺或氨基己酸的p(HEMA)对患有肝脏局灶性病变患者的病理性血液有明显的止血作用。这些止血栓塞材料有望立即控制各种出血；当引入出血增加的区域时，它们可能有助于纠正紊乱的止血。
