利用细菌遗传筛选快速检测亚型选择性核激素受体结合情况
Rapid detection of subtype-selective nuclear hormone receptor binding with bacterial genetic selection.
作者信息
Skretas Georgios, Wood David W
机构信息
Department of Chemical Engineering, Princeton University, Engineering Quadrangle, Olden St., Princeton, NJ 08544, USA.
出版信息
Appl Environ Microbiol. 2005 Dec;71(12):8995-7. doi: 10.1128/AEM.71.12.8995-8997.2005.
Abstract
Subtype-selective nuclear hormone receptor modulators could potentially allow the development of valuable tissue-specific therapeutics. A simple biosensor that allows subtype-specific nuclear hormone receptor binding to be reflected by the growth phenotype of Escherichia coli cells has been constructed. This system will potentially enable the facile detection or evolution of subtype-selective hormone analogues.
摘要
亚型选择性核激素受体调节剂有可能促进有价值的组织特异性疗法的开发。现已构建了一种简单的生物传感器，它能使大肠杆菌细胞的生长表型反映出亚型特异性核激素受体的结合情况。该系统有可能实现对亚型选择性激素类似物的便捷检测或进化。
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3
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