Masclaux F G, Galaud J-P, Pont-Lezica R
Surfaces Cellulaires et Signalisation chez les Végétaux, Unité Mixte de Recherche 5546 de Centre National de la Recherche Scientifique, Université Paul Sabatier, BP 42617 Auzeville, 31326 Castanet-Tolosan, France.
Protoplasma. 2005 Dec;226(3-4):103-8. doi: 10.1007/s00709-005-0117-3. Epub 2005 Dec 12.
Proteins synthesized on membrane-bound ribosomes are sorted at the Golgi apparatus level for delivery to various cellular destinations: the plasma membrane or the extracellular space, and the lytic vacuole or lysosome. Sorting involves the assembly of vesicles, which preferentially package soluble proteins with a common destination. The selection of proteins for a particular vesicle type involves the recognition of proteins by specific receptors, such as the vacuolar sorting receptors for vacuolar targeting. Most eukaryotic organisms have one or two receptors to target proteins to the lytic vacuole. Surprisingly, plants have several members of the same family, seven in Arabidopsis thaliana. Why do plants have so many proteins to sort soluble proteins to their respective destinations? The presence of at least two types of vacuoles, lytic and storage, seems to be a partial answer. In this review we analyze the last experimental evidence supporting the presence of different subfamilies of plant vacuolar sorting receptors.
在膜结合核糖体上合成的蛋白质在高尔基体水平进行分类，以便输送到细胞的各个目的地：质膜或细胞外空间，以及溶酶体或液泡。分类涉及囊泡的组装，囊泡优先包装具有共同目的地的可溶性蛋白质。选择特定囊泡类型的蛋白质涉及特定受体对蛋白质的识别，例如用于液泡靶向的液泡分选受体。大多数真核生物有一到两种将蛋白质靶向溶酶体的受体。令人惊讶的是，植物有同一家族的几个成员，拟南芥中有七个。为什么植物有这么多蛋白质将可溶性蛋白质分选到各自的目的地？至少存在两种类型的液泡，即溶酶体和储存液泡，这似乎是部分答案。在这篇综述中，我们分析了支持植物液泡分选受体不同亚家族存在的最新实验证据。
