Diraa O, Elmdaghri N, Laaboudi L, Boudouma M, Gutiérrez M C, Benbachir M
Microbiology Laboratory, Ibn Rochd University Hospital, Casablanca, Morocco.
Int J Tuberc Lung Dis. 2005 Nov;9(11):1294-6.
Using IS6110 RFLP, 61 isolates recovered from new cases of pulmonary tuberculosis (TB) were compared from September to December 1999 in Casablanca, Morocco, a city with a high incidence of TB. The majority of the isolates (92%) harboured 6-14 copies of IS6110. The minimal fraction of patients in groups of recently acquired infection is 13.1%. This preliminary study showed that IS6110 RFLP is a suitable method for finger-printing Mycobacterium tuberculosis in Casablanca. The unexpectedly low level of recent transmission of TB found in this study deserves further studies involving higher numbers of isolates recovered during a longer recruitment period.
1999年9月至12月期间，在摩洛哥卡萨布兰卡（一个结核病高发城市），运用IS6110限制性片段长度多态性分析方法，对从新诊断的肺结核病例中分离出的61株菌株进行了比较。大多数分离株（92%）含有6 - 14个IS6110拷贝。近期获得性感染组中患者的最小比例为13.1%。这项初步研究表明，IS6110限制性片段长度多态性分析是卡萨布兰卡结核分枝杆菌指纹识别的合适方法。本研究中发现的结核病近期传播水平意外较低，值得在更长的招募期内对更多分离株进行进一步研究。
