Kreft B P, Tanimoto A, Baba Y, Zhao L, Chen J, Middleton M S, Compton C C, Finn J P, Stark D D
Department of Radiology, Massachusetts General Hospital, Boston.
J Magn Reson Imaging. 1992 Jul-Aug;2(4):463-71. doi: 10.1002/jmri.1880020416.
The diagnosis of fatty liver with magnetic resonance (MR) imaging was evaluated in experimental rat models of simple fatty infiltration and fatty liver with hepatocellular injury. T1 and T2 were measured ex vivo and correlated with the histologic degree of fatty infiltration. Enhancement of fatty liver with four different cells-specific contrast agents was studied with ex vivo relaxometry and in vivo MR imaging. Quantitative analysis of conventional and chemical shift MR images was correlated with biochemically determined fat content of the liver. Diet-induced simple fatty infiltration of the liver caused a decrease in T1 of 15%, whereas the T1 of L-ethionine-induced fatty liver with hepatocellular injury increased by 12%. T2 showed a positive correlation with the degree of fatty infiltration in both models. Cell-specific hepatobiliary contrast agents showed the same liver uptake and relaxation enhancement in fatty livers as in normal livers. Conventional T1-weighted images and chemical shift images showed good correlation (r = .83 and .80, respectively) between signal intensity and the degree of fatty infiltration. However, only chemical shift imaging was reliable in the diagnosis of fatty liver.
在单纯性脂肪浸润和伴有肝细胞损伤的脂肪肝的实验大鼠模型中，评估了磁共振（MR）成像对脂肪肝的诊断。在体外测量了T1和T2，并将其与脂肪浸润的组织学程度相关联。使用体外弛豫测量法和体内MR成像研究了四种不同细胞特异性造影剂对脂肪肝的增强作用。对传统和化学位移MR图像的定量分析与生化测定的肝脏脂肪含量相关联。饮食诱导的肝脏单纯性脂肪浸润导致T1降低15%，而L-乙硫氨酸诱导的伴有肝细胞损伤的脂肪肝的T1增加12%。在两种模型中，T2与脂肪浸润程度均呈正相关。细胞特异性肝胆造影剂在脂肪肝中的肝脏摄取和弛豫增强与正常肝脏相同。传统T1加权图像和化学位移图像显示信号强度与脂肪浸润程度之间具有良好的相关性（分别为r = 0.83和0.80）。然而，只有化学位移成像在脂肪肝的诊断中是可靠的。
