Moon Kyung Chul, Lee Geon Kook, Yoo Seong-Ho, Jeon Yoon Kyung, Chung Jin-Haeng, Han Jungho, Chung Doo Hyun
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Anticancer Res. 2005 Nov-Dec;25(6C):4631-7.
Caveolin-1 is implicated in the oncogenic transformation of cells as a tumor suppressor. In several human carcinomas, the expression of caveolin-1 has been reported to be correlated with prognosis. The present study was designed to clarify the clinicopathological significance of caveolin-1 expression in pleomorphic carcinoma of the lung (PCL).
Twenty-one cases of PCL were immunohistochemically evaluated for caveolin-1 expression.
Caveolin-1 was expressed in 18 out of 21 cases. Patients with high caveolin-1 expression in PCL showed lower disease-free and overall survival rates than those with low caveolin-1 expression. However, the expression level of caveolin-1 in PCL was not significantly correlated with age, stage, pT category, pN category, or tumor size.
These results suggest that the overexpression of caveolin-1 is significantly correlated with a poor prognosis in patients with PCL and that it is a marker for predicting prognosis in PCL.
小窝蛋白-1作为一种肿瘤抑制因子参与细胞的致癌转化。在几种人类癌症中，据报道小窝蛋白-1的表达与预后相关。本研究旨在阐明小窝蛋白-1在肺多形性癌（PCL）中的临床病理意义。
对21例PCL患者进行小窝蛋白-1表达的免疫组织化学评估。
21例中有18例表达小窝蛋白-1。PCL中小窝蛋白-1高表达的患者与低表达的患者相比，无病生存率和总生存率较低。然而，PCL中小窝蛋白-1的表达水平与年龄、分期、pT分类、pN分类或肿瘤大小无显著相关性。
这些结果表明，小窝蛋白-1的过表达与PCL患者的不良预后显著相关，并且它是预测PCL预后的一个标志物。
