[Detection of glucocorticoid receptor-alpha mRNA expression using FQ-RT-PCR in nasal polyp].
作者信息
Li Peng, Li Yuan, Zhang Xiaowen, Zhang Gehua, Ye Jin, Sun Yanan, Hu Bin
机构信息
Department of Otolaryngology-Head and Neck Surgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Sep;19(17):769-71.
OBJECTIVE
To detect the expression of the glucocorticoid receptor-alpha (GR-alpha) mRNA in nasal polyp and normal nasal mucosa and investigate the significance of GR-alpha in progression of nasal polyp.
METHOD
The expression of GR-alpha mRNA in 36 samples of nasal polyp and 31 samples of normal nasal mucosa was examined by using fluorescent quantitative PCR(FQ RT-PCR).
RESULT
The GR-alpha mRNA levels in normal nasal mucosa [(135.4 +/- 5.2) x 10(10) copy/g] were significantly higher than those in nasal polyp [(25.5 +/- 5.0) x 10(10) copy/g] (P < 0.01).
CONCLUSION
The low expression of GR-alpha mRNA in nasal polyp is related to the progression of nasal polyp.
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