[胰岛素样生长因子-1受体在鼻息肉中的表达及意义及其与变应性鼻炎的关系]

[The expression and significance of IGF-1R in nasal polyp and its relationship with allergic rhinitis].

作者信息

He Ning, Liang Jianping, Chen Jun, Zhou Xiangyang, Wei Haiming, Zhou Xiangzhen, Wang Tao

机构信息

Department of Otolaryngology-Head and Neck Oncology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Nov;25(22):1019-21, 1024.

PMID:22303694

Abstract

OBJECTIVE

To study the expression of insulin-like growth factor-1 receptor(IGF-1R) in nasal polyps and its relationship with allergic rhinitis.

METHOD

The mRNA and protein expression of IGF-1R in 40 cases (20 cases with allergic rhinitis and 20 cases without) nasal polyps tissue (the CRSWNP group) and 20 middle turbinate tissue samples (the control group) were examined by fluorescence quantitative polymerase chain reaction (FQ-PCR) and immunohistochemistry.

RESULT

The positive staining rate of IGF-1R protein of nasal polyps tissue is 70.8% and that of control is 12.3%, the expression of IGF-1R mRNA of nasal polyp is 0.748 +/- 0.111,which is significant higher than that of the control group is 0.107 +/- 0.208 (P < 0.01). No significant difference of the expression of IGF-1R mRNA between with and without allergic rhinitis cases and between with and without endoscopy sinus surgery history cases in the CRSWNP group.

CONCLUSION

The overexpression of IGF-1R maybe play important roles in the formation of nasal polyp. Hypersensitivity reaction type I mediated by IgE has no contribution to the overexpression of the IGF-1R.

摘要

目的

研究胰岛素样生长因子-1受体（IGF-1R）在鼻息肉中的表达及其与变应性鼻炎的关系。

方法

采用荧光定量聚合酶链反应（FQ-PCR）和免疫组织化学方法检测40例鼻息肉组织（慢性鼻窦炎伴鼻息肉组，其中变应性鼻炎患者20例，非变应性鼻炎患者20例）及20例中鼻甲组织标本（对照组）中IGF-1R的mRNA和蛋白表达。

结果

鼻息肉组织中IGF-1R蛋白阳性染色率为70.8%，对照组为12.3%；鼻息肉组织中IGF-1R mRNA表达量为0.748±0.111，显著高于对照组的0.107±0.208（P<0.01）。慢性鼻窦炎伴鼻息肉组中，有变应性鼻炎与无变应性鼻炎患者之间、有内镜鼻窦手术史与无内镜鼻窦手术史患者之间IGF-1R mRNA表达差异无统计学意义。