通过无脊椎动物遗传学了解癌症基因。

Learning about cancer genes through invertebrate genetics.

作者信息

Hoffmann F M, Sternberg P W, Herskowitz I

机构信息

McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.

出版信息

Curr Opin Genet Dev. 1992 Feb;2(1):45-52. doi: 10.1016/s0959-437x(05)80320-x.

DOI:10.1016/s0959-437x(05)80320-x

PMID:1633426

Abstract

Genetic studies in yeast, nematodes and Drosophila are revealing the signal transduction pathways that regulate differentiation and cell proliferation. Some of the critical molecules involved are homologous to proto-oncogenes and others are likely to be analogous to the products of tumor suppressor genes.

摘要

对酵母、线虫和果蝇的基因研究正在揭示调节分化和细胞增殖的信号转导途径。其中一些关键分子与原癌基因同源，而其他一些分子可能类似于肿瘤抑制基因的产物。