[The relationship between the concentration of TGF-beta1 in serum and its gene polymorphisms in CWP].

OBJECTIVE

To study the relationship between the concentration of TGF-beta1, in serum and its gene polymorphisms in CWP.

METHODS

101 cases of coal worker's pneumoconiosis (CWP)were selected. And the peripheral vein blood samples were collected from them. The concentration of TGF-beta1 of their serum were detected with the TGF-beta1 ELISA kit. And their TGF-beta1 gene -509 site polymorphisms were analyzed with the polymerse chain reaction-restriction fragment length polymorphisms (PCR-RFLP) techniques.

RESULTS

The mean value of TGF-beta1, concentration in serum of T/T, C/T and C/C gene type group were 90 ml, 60 ml and 55.960 +/- 28.833 ng/ ml respectively. Significant differences were observed within the three groups (P<0.05). The differences of the mean value of TGF-beta1, concentration in serum in various work years groups, age groups and in the groups with different stage of pneumoconiosis were not significant (P > 0.05).

CONCLUSION

The correlative relationship between the concentration of transforming growth factor I (TGF-beta1) in serum and its gene -509 site polymorphisms might be occurring.