Wang Bo, Liu Heng-Chuan, Ju Chang-Yan
Department of Medical Technology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Nov;36(6):858-61.
To illuminate the role of water-soluble, 650 ml/L edible alcohol and 950 ml/L edible alcohol-soluble extracts of wild Psidium guajava leaves in Panzhihua Area in decreasing blood glucose.
High-level blood glucose models were made by use of male Kunming mice given intraperitoneal injection of glucose, subcutaneous injection of adrenaline and intraperitoneal injection of streptozotocin (STZ), respectively. Blood glucose concentration was measured after oral administration (gastrogavage) of the soluble extracts of Psidium guajava leaves, respectively. Body weight and organ morphology were observed, and organ index was obtained. The All available indexes were statistically analyzed in comparing the study groups and control group.
three extracts resisted the rise of blood glucose level induced by exogenous glucose and adrenaline to various degrees. The extracts of water, 650 ml/L alcohol and 950 ml/L alcohol significantly decreased the blood glucose level in STZ-induced diabetic mice by 36.3%, 33.5% and 31.3% respectively. Furthermore, among three extracts, water-soluble extract showed little influence on the growth of mice.
The water-soluble, 650 ml/L edible alcohol and 950 ml/L edible alcohol-soluble extracts of wild Psidium guajava leaves in Panzhihua area may have different hypoglycemic potential.
阐明攀枝花地区野生番石榴叶的水溶性、650 ml/L食用酒精溶性及950 ml/L食用酒精溶性提取物在降血糖方面的作用。
分别采用腹腔注射葡萄糖、皮下注射肾上腺素及腹腔注射链脲佐菌素（STZ）的方法建立雄性昆明小鼠高血糖模型。分别灌胃给予番石榴叶可溶性提取物后测定血糖浓度。观察体重及器官形态，并计算器官指数。对各研究组与对照组的所有可用指标进行统计学分析。
三种提取物均不同程度地抵抗外源性葡萄糖和肾上腺素引起的血糖水平升高。水、650 ml/L酒精及950 ml/L酒精提取物使STZ诱导的糖尿病小鼠血糖水平分别显著降低36.3%、33.5%和31.3%。此外，三种提取物中，水溶性提取物对小鼠生长影响较小。
攀枝花地区野生番石榴叶的水溶性、650 ml/L食用酒精溶性及950 ml/L食用酒精溶性提取物可能具有不同的降血糖潜力。
