Jun Zhou, Fang Suping, Huo Hairu, Qi Yun, Guo Shuying, Jiang Tingliang, Shi Qi
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
J Tradit Chin Med. 2005 Sep;25(3):222-5.
After the rat model of cervical spondylosis was developed for 6 months, the PGE2 content and COX activity in the cervical intervertebral discs were determined respectively by radioimmunoassay and catalytic activity assay. The results indicated that the PGE2 content and COX activity in the model rat increased significantly, and that Ge Gen Decoction could down-regulate the PGE2 content and inhibit COX activity. This is possibly one of the mechanisms of Ge Gen Decoction for treating cervical spondylosis.
将大鼠颈椎病模型造模6个月后，分别采用放射免疫分析法和催化活性测定法测定颈椎间盘组织中PGE2含量和COX活性。结果显示，模型大鼠的PGE2含量和COX活性显著升高，而葛根汤可下调PGE2含量并抑制COX活性。这可能是葛根汤治疗颈椎病的机制之一。
