Hosokawa Ayumu, Shimada Yasuhiro, Matsumura Yasuhiro, Yamada Yasuhide, Muro Kei, Hamaguchi Tetsuya, Igaki Hiroyasu, Tachimori Yuji, Kato Hoichi, Shirao Kuniaki
Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
Hepatogastroenterology. 2005 Nov-Dec;52(66):1738-41.
BACKGROUND/AIMS: The aims of this study are to retrospectively analyze data on the epidemiology, clinical characteristics, and treatment outcomes of 14 cases of small cell carcinoma of the esophagus.
Patient records were reviewed for data on demographics, presenting symptoms, diagnosis, disease stage, type of treatment and outcome.
Between January 1990 and December 2001, 14 patients with small cell carcinoma of the esophagus were treated at the National Cancer Center Hospital, representing 0.8% of all esophageal carcinomas diagnosed during this period. Eleven patients presented with extensive disease at the time of diagnosis, while three patients were noted to have limited disease. Nine patients received combination chemotherapy with or without radiotherapy. Three of these patients achieved a complete response to first-line treatment and two of them have survived more than two years. Five patients underwent esophagectomy as an initial treatment with curative intent. All of these patients developed early relapse after esophagectomy, and only one patient has survived more than two years. The overall median survival was 7.7 months (range: 0.6-89.1 months) for all 14 patients.
Although curative esophagectomy may be effective as a primary treatment in some patients, systemic chemotherapy with or without concurrent radiotherapy should be considered as an important treatment option for small cell carcinoma of the esophagus.
背景/目的：本研究旨在回顾性分析14例食管小细胞癌的流行病学、临床特征及治疗结果数据。
查阅患者病历，获取人口统计学、症状表现、诊断、疾病分期、治疗类型及结果等数据。
1990年1月至2001年12月期间，国立癌症中心医院共治疗了14例食管小细胞癌患者，占同期确诊的所有食管癌患者的0.8%。11例患者诊断时已出现广泛病变，3例患者病变局限。9例患者接受了联合化疗，部分联合放疗。其中3例患者对一线治疗完全缓解，2例存活超过两年。5例患者接受了旨在治愈的食管切除术作为初始治疗。所有这些患者在食管切除术后均早期复发，仅1例患者存活超过两年。14例患者的总体中位生存期为7.7个月（范围：0.6 - 89.1个月）。
尽管根治性食管切除术在部分患者中作为初始治疗可能有效，但对于食管小细胞癌，应考虑全身化疗联合或不联合同期放疗作为重要的治疗选择。
