Bennouna J, Douillard J Y, Bardet E, Maury B
Centre René-Gauducheau, Saint-Herblain, France.
Bull Cancer. 1997 Dec;84(12):1109-14.
Small-cell carcinomas of the esophagus are a rare and aggressive tumors with early widespread dissemination. Despite the use of different therapeutic modalities, the prognosis remains poor. Between 1993 and 1995, 5 patients with small-cell carcinoma of the esophagus were treated at René-Gauducheau Center, representing 2.8% of all esophageal malignancies diagnosed during this period. Three patients presented with limited disease while 2 patients had distant metastases at the time of diagnosis. Primary treatment consisted of polychemotherapy in all patients and a complete response was observed in three cases. These 3 patients had received subsequent radiotherapy, and endoesophageal brachytherapy in 2 cases. In this article, we report our experience of patients with this tumor and attempt to make comparisons with the cases published in the literature, regarding location, symptomatology, histopathologic diagnosis and treatment of this tumor. We conclude that the optimum treatment seems to be the same as for small-cell carcinoma of the lung, a multidrug combination chemotherapy regimen used alone or with sequential radiation.
食管小细胞癌是一种罕见且侵袭性强的肿瘤，早期即可广泛播散。尽管采用了不同的治疗方式，但其预后仍然很差。1993年至1995年间，勒内 - 高杜乔中心收治了5例食管小细胞癌患者，占该时期诊断出的所有食管恶性肿瘤的2.8%。3例患者初诊时疾病局限，2例患者诊断时已有远处转移。所有患者的初始治疗均为多药化疗，3例患者观察到完全缓解。这3例患者随后接受了放疗，其中2例还接受了食管内近距离放疗。在本文中，我们报告了我们对该肿瘤患者的治疗经验，并试图就该肿瘤的位置、症状、组织病理学诊断和治疗与文献中报道的病例进行比较。我们得出结论，最佳治疗方案似乎与肺癌小细胞癌相同，即单独使用或与序贯放疗联合使用的多药联合化疗方案。
