Viallard Jean-Francois, Lazaro Estibaliz, Lafon Marie-Edith, Pellegrin Jean-Luc
Service de Médecine Interne et Maladies Infectieuses, Hôpital Haut-Lévâque, 33604 Pessac Cedex, France.
Leuk Lymphoma. 2005 Nov;46(11):1659-62. doi: 10.1080/10428190500177995.
Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating infectious disease, caused by the human polyomavirus JC (JCV), that usually occurs in immunocompromised patients. In this setting, PML has been observed in increasing numbers of patients with hematological malignancies, mostly lymphoproliferative B-cell disorders. Despite attempts with various drugs, PML has generally remained unresponsive to treatment. We report the successful use of cidofovir in a patient who developed PML 6 months before angioimmunoblastic T-cell lymphoma (AITL) was diagnosed. To the best of our knowledge, this is the first case of PML in AITL. Our case demonstrates the expanding clinical importance of PML in hematological conditions, and neurological symptoms and/or white matter changes on central nervous system imaging should arouse the suspicion of PML and lead to rapid cidofovir introduction. Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating infectious disease, caused by the human polyomavirus JC (JCV), that usually occurs in immunocompromised patients. In this setting, PML has been observed in increasing numbers of patients with hematological malignancies, mostly lymphoproliferative B-cell disorders. Despite attempts with various drugs, PML has generally remained unresponsive to treatment. We report the successful use of cidofovir in a patient who developed PML 6 months before angioimmunoblastic T-cell lymphoma (AITL) was diagnosed. To the best of our knowledge, this is the first case of PML in AITL. Our case demonstrates the expanding clinical importance of PML in hematological conditions, and neurological symptoms and/or white matter changes on central nervous system imaging should arouse the suspicion of PML and lead to rapid cidofovir introduction.
进行性多灶性白质脑病（PML）是一种由人多瘤病毒JC（JCV）引起的亚急性脱髓鞘感染性疾病，通常发生在免疫功能低下的患者中。在这种情况下，越来越多的血液系统恶性肿瘤患者出现了PML，其中大多数是淋巴细胞增生性B细胞疾病。尽管尝试了各种药物治疗，但PML通常对治疗无反应。我们报告了一名在血管免疫母细胞性T细胞淋巴瘤（AITL）诊断前6个月发生PML的患者成功使用西多福韦治疗的病例。据我们所知，这是AITL患者中首例PML病例。我们的病例表明PML在血液系统疾病中的临床重要性不断增加，中枢神经系统成像上的神经症状和/或白质改变应引起对PML的怀疑，并促使迅速引入西多福韦治疗。进行性多灶性白质脑病（PML）是一种由人多瘤病毒JC（JCV）引起的亚急性脱髓鞘感染性疾病，通常发生在免疫功能低下的患者中。在这种情况下，越来越多的血液系统恶性肿瘤患者出现了PML，其中大多数是淋巴细胞增生性B细胞疾病。尽管尝试了各种药物治疗，但PML通常对治疗无反应。我们报告了一名在血管免疫母细胞性T细胞淋巴瘤（AITL）诊断前6个月发生PML的患者成功使用西多福韦治疗的病例。据我们所知，这是AITL患者中首例PML病例。我们的病例表明PML在血液系统疾病中的临床重要性不断增加，中枢神经系统成像上的神经症状和/或白质改变应引起对PML的怀疑，并促使迅速引入西多福韦治疗。
