Díaz-Rubio Manuel
Department of Medical Pathology, Gastroenterology Service, San Carlos Clinical University Hospital, Universidad Complutense, Madrid, Spain.
Drugs. 2005;65 Suppl 1:1-6. doi: 10.2165/00003495-200565001-00002.
The inhibition of gastric secretion has been a therapeutic objective for decades. A variety of pharmacologic and non-pharmacologic approaches have been proposed throughout history. Among the non-pharmacologic proposals, gastric surgery was widely used until effective drugs were available. Initially antacids and later anticholinergics, H2 blockers and proton pump inhibitors took the predominant position. Finally, Helicobacter pylori eradication has been the milestone for the cure of peptic ulcers.
几十年来，抑制胃酸分泌一直是治疗目标。历史上已经提出了多种药物和非药物方法。在非药物方法中，在有效药物出现之前，胃手术被广泛使用。最初是抗酸剂，后来是抗胆碱能药物、H2受体阻滞剂和质子泵抑制剂占据了主导地位。最后，根除幽门螺杆菌成为消化性溃疡治愈的里程碑。
