Kawashita Milka Yuri, Tsai Katia, Aoki Valéria, Santi Claudia Giuli, Maruta Celina Wakisaka, Rivitti Evandro
Department of Dermatology of University of Sao Paulo, Brazil.
J Dermatol. 2005 Jul;32(7):574-80. doi: 10.1111/j.1346-8138.2005.tb00801.x.
Pemphigus foliaceus is an autoimmune cutaneous disease with subcorneal acantholysis and pathogenic IgG4 autoantibodies directed against desmoglein 1. We present our experience with mycophenolate mofetil (MMF) in the treatment of one case of endemic pemphigus foliaceus (fogo selvagem) and two cases of the classic form. All patients had severe, refractory disease and developed marked adverse effects due to long-term corticosteroid therapy. MMF proved to be an effective corticosteroid-sparing agent at doses varying from 35 to 45 mg/kg/d. It was well tolerated, and we found no significant adverse effects from this drug.
落叶型天疱疮是一种自身免疫性皮肤病，具有角层下棘层松解，且有针对桥粒芯糖蛋白1的致病性IgG4自身抗体。我们介绍了霉酚酸酯（MMF）治疗1例地方性落叶型天疱疮（丛林大疱疮）和2例经典型病例的经验。所有患者均患有严重的难治性疾病，且因长期使用糖皮质激素治疗而出现明显的不良反应。MMF在35至45mg/kg/d的剂量下被证明是一种有效的糖皮质激素节约剂。它耐受性良好，我们未发现该药物有明显的不良反应。
