Johansson Björn P, Levander Fredrik, von Pawel-Rammingen Ulrich, Berggård Tord, Björck Lars, James Peter
Department of Clinical Sciences, Lund University, Lund, Sweden.
J Proteome Res. 2005 Nov-Dec;4(6):2302-11. doi: 10.1021/pr050217y.
During the course of infection, the common human pathogen Streptococcus pyogenes encounters plasma. We show that plasma causes S. pyogenes to rapidly remodel its cellular metabolism and virulence pathways. We also identified a variant of the major virulence factor, M1 protein, lacking 13 amino acids at the NH(2)-terminus in bacteria grown with plasma. The pronounced effect of plasma on protein expression, suggests this is an important adaptive mechanism with implications for S. pyogenes pathogenicity.
在感染过程中，常见的人类病原体化脓性链球菌会接触到血浆。我们发现，血浆会使化脓性链球菌迅速重塑其细胞代谢和毒力途径。我们还鉴定出一种主要毒力因子M1蛋白的变体，在用血浆培养的细菌中，该变体在NH(2)末端缺少13个氨基酸。血浆对蛋白质表达有显著影响，这表明这是一种重要的适应性机制，对化脓性链球菌的致病性有影响。
