Willkomm Dagmar K, Hartmann Roland K
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, D-35037 Marburg, Germany.
Biol Chem. 2005 Dec;386(12):1273-7. doi: 10.1515/BC.2005.144.
The bacterial riboregulator 6S RNA was one of the first non-coding RNAs to be discovered in the late 1960s, but its cellular role remained enigmatic until the year 2000. 6S RNA, only recognized to be ubiquitous among bacteria in 2005, binds to RNA polymerase in a sigma factor-dependent manner to repress transcription from a subgroup of promoters. The common feature of a double-stranded rod with a central bulge has led to the proposal that 6S RNA may mimic an open promoter complex.
细菌核糖调节因子6S RNA是20世纪60年代末最早发现的非编码RNA之一，但直到2000年其细胞功能仍不清楚。6S RNA直到2005年才被认为在细菌中普遍存在，它以依赖sigma因子的方式与RNA聚合酶结合，从而抑制一组启动子的转录。具有中央凸起的双链杆状结构的共同特征，使人提出6S RNA可能模拟开放启动子复合物的观点。
