Cohen M M, Kreiborg S
Department of Oral Biology, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada.
Clin Genet. 1992 Jan;41(1):12-5. doi: 10.1111/j.1399-0004.1992.tb03620.x.
An indirect method for estimating the birth prevalence of the Crouzon syndrome is presented. The fraction of Crouzon syndrome patients in large clinical surveys of all cases of craniosynostosis is calculated and the fractional component obtained is multiplied by the known birth prevalence of craniosynostosis in general. Crouzon syndrome makes up approximately 4.8% of all cases of craniosynostosis. Using a weighted average estimate, birth prevalence was calculated to be 16.5/1,000,000. The results of the indirect method compare favorably with those obtained by the direct method. Nevertheless, because the indirect method is based on a number of assumptions that are easily violated, we cannot recommend its general use except under special circumstances.
本文介绍了一种估算克鲁宗综合征出生患病率的间接方法。计算在所有颅缝早闭病例的大型临床调查中克鲁宗综合征患者的比例，然后将所得的比例成分乘以一般已知的颅缝早闭出生患病率。克鲁宗综合征约占所有颅缝早闭病例的4.8%。采用加权平均估计，计算出出生患病率为16.5/1,000,000。间接法的结果与直接法所得结果相比具有优势。然而，由于间接法基于一些容易被违反的假设，我们不建议在特殊情况以外普遍使用该方法。
