Rosenberger Georg, Kutsche Kerstin
Institut für Humangenetik, Universitätsklinikum Hamburg-Eppendorf, Butenfeld 42, 22529 Hamburg, Germany.
Eur J Cell Biol. 2006 Apr;85(3-4):265-74. doi: 10.1016/j.ejcb.2005.10.007. Epub 2005 Dec 5.
Alpha and betaPIX belong to the group of guanine nucleotide exchange factors (GEFs) that mediate activation of members of the Rho GTPase family, in particular Rac1 and Cdc42, by stimulating the exchange of GDP for GTP. Rho family proteins are well known as regulators of the actin cytoskeleton and have been implicated in the formation of various types of focal adhesion structures. However, the function of GEF proteins during focal adhesion formation is only beginning to emerge. Here, we highlight the recent findings on alpha and betaPIX and their involvement in integrin-dependent signaling and suggest models for the role of PIX proteins during focal adhesion turnover.
α-PIX和β-PIX属于鸟嘌呤核苷酸交换因子（GEF）家族，它们通过刺激GDP与GTP的交换来介导Rho GTPase家族成员（特别是Rac1和Cdc42）的激活。Rho家族蛋白作为肌动蛋白细胞骨架的调节剂而广为人知，并与各种类型的粘着斑结构的形成有关。然而，GEF蛋白在粘着斑形成过程中的功能才刚刚开始显现。在这里，我们重点介绍了关于α-PIX和β-PIX的最新发现及其在整合素依赖性信号传导中的作用，并提出了PIX蛋白在粘着斑周转过程中作用的模型。
