硫酸镁用于早产和子痫前期治疗期间的血清离子镁
Serum ionized magnesium during magnesium sulfate administration for preterm labor and preeclampsia.
作者信息
Yoshida Mayumi, Matsuda Yoshio, Akizawa Yoshika, Ono Erina, Ohta Hiroaki
机构信息
Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2006 Sep-Oct;128(1-2):125-8. doi: 10.1016/j.ejogrb.2005.10.036. Epub 2005 Dec 5.
OBJECTIVE
The purpose of this study is to estimate the relations between ionized and total Mg levels during MgSO4 administration in patients with preterm labor and preeclampsia.
METHODS
Forty-three pregnant patients who were candidates for MgSO4 were studied (preterm labor, 27; preeclampsia, 16). The administration method was intravenous injection of MgSO4 4 g over 30 min followed by 1-2 g/h. Ionized Mg was measured by the selective ion electrode method at bedside, and compared it with total Mg levels.
RESULTS
Significant correlation was existed between levels of ionized and total Mg throughout therapy for both preterm labor (ionized Mg=0.19 x total Mg+0.19; r=0.61, p<0.001) and preeclampsia (ionized Mg=0.20 x total Mg+0.14; r=0.60, p<0.001).
CONCLUSION
There are correlations between ionized and total Mg levels during administration of MgSO4 for both preterm labor and preeclampsia.
目的
本研究旨在评估硫酸镁治疗早产和子痫前期患者期间，离子镁水平与总镁水平之间的关系。
方法
对43例可能使用硫酸镁治疗的孕妇进行研究（早产27例；子痫前期16例）。给药方法为静脉注射硫酸镁4g，30分钟推注完毕，随后以1-2g/小时持续静脉滴注。采用选择性离子电极法在床旁测定离子镁，并与总镁水平进行比较。
结果
早产患者（离子镁=0.19×总镁+0.19；r=0.61，p<0.001）和子痫前期患者（离子镁=0.20×总镁+0.14；r=0.60，p<0.001）在整个治疗过程中，离子镁水平与总镁水平均存在显著相关性。
结论
硫酸镁治疗早产和子痫前期患者期间，离子镁水平与总镁水平之间存在相关性。
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