Hiett A K, Devoe L D, Brown H L, Watson J
Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, USA.
Am J Perinatol. 1995 Jul;12(4):259-61. doi: 10.1055/s-2007-994468.
We studied 16 women, at 32 weeks' or more gestation who required magnesium sulfate (MgSO4) therapy for preterm labor or preeclampsia. A 60-minute Doppler fetal heart rate (FHR) tracing, analyzed by the Oxford Sonicaid System 8000, was obtained for 1 hour before and 2 hours after each patient received intravenous MgSO4 therapy. Maternal serum Mg2+ levels were obtained at the second monitoring session. Matched paired measures of FHR parameters were compared with the Student's t test. After MgSO4 administration, we noted significant falls in long-term variability, short-term variability, and total acceleration (more than 10 beats/min) counts. Reduced short-term and overall variability occurred in all cases with maternal serum Mg2+ levels more than 4.6 mg/dL. Therapeutic maternal serum Mg2+ levels are linked with decreases in long-term and short-term FHR variability and acceleration counts. These findings should be considered when evaluating resting FHR baseline of patients thus treated.
我们研究了16名妊娠32周及以上、因早产或先兆子痫需要硫酸镁（MgSO4）治疗的女性。在每位患者接受静脉硫酸镁治疗前1小时和治疗后2小时，采用牛津索奈卡特系统8000分析，获取60分钟的多普勒胎儿心率（FHR）记录。在第二次监测时获取母体血清镁离子（Mg2+）水平。采用学生t检验比较FHR参数的配对测量值。硫酸镁给药后，我们注意到长期变异性、短期变异性和总加速（超过10次/分钟）计数显著下降。所有母体血清镁离子水平超过4.6mg/dL的病例均出现短期和整体变异性降低。治疗性母体血清镁离子水平与FHR长期和短期变异性及加速计数的降低有关。在评估接受此类治疗患者的静息FHR基线时应考虑这些发现。
