基于社区的双胞胎样本中哮喘与肥胖之间的遗传多效性。
Genetic pleiotropy between asthma and obesity in a community-based sample of twins.
作者信息
Hallstrand Teal S, Fischer Mary E, Wurfel Mark M, Afari Niloofar, Buchwald Dedra, Goldberg Jack
机构信息
Department of Medicine, University of Washington, Seattle, 98195, USA.
出版信息
J Allergy Clin Immunol. 2005 Dec;116(6):1235-41. doi: 10.1016/j.jaci.2005.09.016. Epub 2005 Nov 8.
BACKGROUND
Asthma and obesity are common conditions that are strongly associated. This association might be due to shared genetic or environmental causes.
OBJECTIVE
We sought to determine whether a shared genetic cause is responsible for the association between asthma and obesity and to estimate the magnitude of shared genetic cause.
METHODS
The analyses were performed with 1001 monozygotic and 383 dizygotic same-sex twin pairs within the University of Washington Twin Registry. The presence of asthma was determined by self-report of a physician diagnosis of asthma, and body mass index (BMI) was calculated by using self-reported height and weight. Obesity was defined as a BMI of 30 or greater. The association between asthma and BMI was assessed by means of mixed-effects ordinal regression. Twin correlations examined the association of asthma and obesity. Univariate and bivariate structural equation models estimated the components of variance attributable to genetic and environmental effects.
RESULTS
A strong association between asthma and BMI was identified in the sample population (P < .001). Substantial heritability was detected for asthma (53%) and obesity (77%), which is indicative of additive genetic influences on each disorder. The best-fitting model of shared components of variance indicated that 8% of the genetic component of obesity is shared with asthma.
CONCLUSION
The covariation between obesity and asthma is predominantly caused by shared genetic risk factors for both conditions.
背景
哮喘和肥胖是密切相关的常见病症。这种关联可能归因于共同的遗传或环境因素。
目的
我们试图确定哮喘与肥胖之间的关联是否由共同的遗传因素所致，并估算共同遗传因素的影响程度。
方法
分析采用了华盛顿大学双胞胎登记处的1001对同卵双胞胎和383对同性异卵双胞胎。哮喘的存在通过医生诊断哮喘的自我报告来确定，体重指数（BMI）通过自我报告的身高和体重计算得出。肥胖定义为BMI为30或更高。哮喘与BMI之间的关联通过混合效应有序回归进行评估。双胞胎相关性检验了哮喘与肥胖之间的关联。单变量和双变量结构方程模型估计了遗传和环境效应所致的方差成分。
结果
在样本人群中发现哮喘与BMI之间存在强关联（P <.001）。检测到哮喘（53%）和肥胖（77%）有显著的遗传度，这表明每种疾病都受到加性遗传影响。最佳拟合的共同方差成分模型表明，肥胖的遗传成分中有8%与哮喘共有。
结论
肥胖与哮喘之间的协变主要由这两种病症的共同遗传风险因素所致。
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