Cordin Olivier, Banroques Josette, Tanner N Kyle, Linder Patrick
Département de Microbiologie et Médecine Moléculaire, Centre Médical Universitaire, 1 rue Michel Servet, 1211, Genève 4, Switzerland.
Gene. 2006 Feb 15;367:17-37. doi: 10.1016/j.gene.2005.10.019. Epub 2005 Dec 7.
RNA helicases of the DEAD-box protein family have been shown to participate in every aspect of RNA metabolism. They are present in most organisms where they work as RNA helicases or RNPases. The properties of these enzymes in vivo remains poorly described, however some were extensively characterized in vitro, and the solved crystal structures of a few are now available. Taken together, this information gives insight into the regulation of ATP and RNA binding as well as in the ATPase and helicase activities. This review will focus on the description of the molecular characteristics of members of the DEAD-box protein family and on the enzymatic activities they possess.
已证明DEAD盒蛋白家族的RNA解旋酶参与RNA代谢的各个方面。它们存在于大多数生物体中，在那里作为RNA解旋酶或核糖核蛋白酶发挥作用。然而，这些酶在体内的特性仍描述甚少，不过有些已在体外得到广泛表征，现在已有少数几种酶的晶体结构被解析出来。综合这些信息，有助于深入了解ATP和RNA结合的调控以及ATP酶和解旋酶的活性。本综述将着重描述DEAD盒蛋白家族成员的分子特征及其所具有的酶活性。
