Zhuang BinQuan, Sockanathan Shanthini
Preclinical Teaching Building, 1004, Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Curr Opin Neurobiol. 2006 Feb;16(1):20-4. doi: 10.1016/j.conb.2005.11.001. Epub 2005 Dec 7.
The generation of dorsal interneurons in the spinal cord is dependent upon specific signaling pathways and the subsequent establishment of progenitor domains mediated by cross-repressive interactions of different groups of transcription factors. These events lead to the implementation of specific differentiation programs that direct the development of distinct dorsal interneuron subtypes. Recent studies have taken advantage of complementary gain and loss-of-function studies in the chick and mouse to clarify the in vivo roles of transforming growth factor beta signaling, basic helix-loop-helix and homeodomain transcription factors in dorsal interneuron development. The challenge now lies in identifying the precise molecular mechanisms involved and applying these insights to understanding how more ventrally located dorsal interneurons are specified.
脊髓中背侧中间神经元的产生依赖于特定的信号通路以及由不同转录因子组之间的相互抑制性相互作用介导的祖细胞区域的后续建立。这些事件导致特定分化程序的实施，这些程序指导不同背侧中间神经元亚型的发育。最近的研究利用了鸡和小鼠中互补的功能获得和功能丧失研究，以阐明转化生长因子β信号传导、碱性螺旋-环-螺旋和同源结构域转录因子在背侧中间神经元发育中的体内作用。现在的挑战在于确定所涉及的精确分子机制，并将这些见解应用于理解更位于腹侧的背侧中间神经元是如何被指定的。
