发育中脊髓的背侧连合轴突导向。
Dorsal commissural axon guidance in the developing spinal cord.
机构信息
Department of Neurobiology, University of California, Los Angeles, CA, United States; Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, CA, United States.
Department of Neurobiology, Stanford University, Palo Alto, CA, United States.
出版信息
Curr Top Dev Biol. 2021;142:197-231. doi: 10.1016/bs.ctdb.2020.10.009. Epub 2020 Nov 19.
Abstract
Commissural axons have been a key model system for identifying axon guidance signals in vertebrates. This review summarizes the current thinking about the molecular and cellular mechanisms that establish a specific commissural neural circuit: the dI1 neurons in the developing spinal cord. We assess the contribution of long- and short-range signaling while sequentially following the developmental timeline from the birth of dI1 neurons, to the extension of commissural axons first circumferentially and then contralaterally into the ventral funiculus.
摘要
连合轴突一直是鉴定脊椎动物轴突导向信号的重要模型系统。本综述总结了目前关于建立特定连合神经回路（发育中的脊髓中的 dI1 神经元）的分子和细胞机制的思考。我们评估了长程和短程信号的贡献，同时沿着从 dI1 神经元诞生开始的发育时间轴，依次追踪轴突的延伸，先是周向延伸，然后再向对侧延伸到腹索中。
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