发育中脊髓的背侧连合轴突导向。
Dorsal commissural axon guidance in the developing spinal cord.
机构信息
Department of Neurobiology, University of California, Los Angeles, CA, United States; Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, CA, United States.
Department of Neurobiology, Stanford University, Palo Alto, CA, United States.
出版信息
Curr Top Dev Biol. 2021;142:197-231. doi: 10.1016/bs.ctdb.2020.10.009. Epub 2020 Nov 19.
Abstract
Commissural axons have been a key model system for identifying axon guidance signals in vertebrates. This review summarizes the current thinking about the molecular and cellular mechanisms that establish a specific commissural neural circuit: the dI1 neurons in the developing spinal cord. We assess the contribution of long- and short-range signaling while sequentially following the developmental timeline from the birth of dI1 neurons, to the extension of commissural axons first circumferentially and then contralaterally into the ventral funiculus.
摘要
连合轴突一直是鉴定脊椎动物轴突导向信号的重要模型系统。本综述总结了目前关于建立特定连合神经回路（发育中的脊髓中的 dI1 神经元）的分子和细胞机制的思考。我们评估了长程和短程信号的贡献，同时沿着从 dI1 神经元诞生开始的发育时间轴，依次追踪轴突的延伸，先是周向延伸，然后再向对侧延伸到腹索中。
相似文献
1
Dorsal commissural axon guidance in the developing spinal cord.
Curr Top Dev Biol. 2021;142:197-231. doi: 10.1016/bs.ctdb.2020.10.009. Epub 2020 Nov 19.
2
Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells.
Neuron. 2019 Feb 20;101(4):635-647.e4. doi: 10.1016/j.neuron.2018.12.025. Epub 2019 Jan 17.
3
Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord.
Neuron. 2017 May 17;94(4):790-799.e3. doi: 10.1016/j.neuron.2017.03.007. Epub 2017 Apr 21.
4
Netrin1-DCC-Mediated Attraction Guides Post-Crossing Commissural Axons in the Hindbrain.
J Neurosci. 2015 Aug 19;35(33):11707-18. doi: 10.1523/JNEUROSCI.0613-15.2015.
5
The spinal cord shows the way - How axons navigate intermediate targets.
Dev Biol. 2017 Dec 1;432(1):43-52. doi: 10.1016/j.ydbio.2016.12.002. Epub 2016 Dec 10.
6
Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance.
J Neurosci. 2010 Jul 14;30(28):9445-53. doi: 10.1523/JNEUROSCI.6290-09.2010.
7
Robo family of proteins exhibit differential expression in mouse spinal cord and Robo-Slit interaction is required for midline crossing in vertebrate spinal cord.
Dev Dyn. 2005 May;233(1):41-51. doi: 10.1002/dvdy.20324.
8
Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.
PLoS One. 2011;6(5):e19887. doi: 10.1371/journal.pone.0019887. Epub 2011 May 31.
9
Cables1 links Slit/Robo and Wnt/Frizzled signaling in commissural axon guidance.
Development. 2023 Oct 1;150(19). doi: 10.1242/dev.201671. Epub 2023 Oct 9.
10
Real time large scale in vivo observations reveal intrinsic synchrony, plasticity and growth cone dynamics of midline crossing axons at the ventral floor plate of the zebrafish spinal cord.
J Integr Neurosci. 2019 Dec 30;18(4):351-368. doi: 10.31083/j.jin.2019.04.1191.
引用本文的文献
1
MYC regulation of the miR-92-Robo1 axis in Slit-mediated commissural axon guidance.
Mol Biol Cell. 2025 Apr 1;36(4):ar50. doi: 10.1091/mbc.E24-12-0534. Epub 2025 Feb 28.
2
Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling.
Cell Rep. 2024 Nov 26;43(11):114954. doi: 10.1016/j.celrep.2024.114954. Epub 2024 Nov 14.
3
Integrin-mediated electric axon guidance underlying optic nerve formation in the embryonic chick retina.
Commun Biol. 2023 Jun 30;6(1):680. doi: 10.1038/s42003-023-05056-x.
4
Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system.
Nat Commun. 2022 Oct 13;13(1):6040. doi: 10.1038/s41467-022-33799-4.
本文引用的文献
1
NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.
Nat Commun. 2020 Mar 20;11(1):1489. doi: 10.1038/s41467-020-15211-1.
2
Commissural axon guidance in the developing spinal cord: from Cajal to the present day.
Neural Dev. 2019 Sep 12;14(1):9. doi: 10.1186/s13064-019-0133-1.
3
Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian and .
Elife. 2019 Aug 8;8:e46042. doi: 10.7554/eLife.46042.
4
BMP4 patterns Smad activity and generates stereotyped cell fate organization in spinal organoids.
Development. 2019 Jul 25;146(14):dev175430. doi: 10.1242/dev.175430.
5
Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3 mouse.
J Comp Neurol. 2019 Dec 15;527(18):2948-2972. doi: 10.1002/cne.24720. Epub 2019 Jun 14.
6
Roles of axon guidance molecules in neuronal wiring in the developing spinal cord.
Nat Rev Neurosci. 2019 Jul;20(7):380-396. doi: 10.1038/s41583-019-0168-7.
7
Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord.
Cell Rep. 2019 Mar 19;26(12):3298-3312.e4. doi: 10.1016/j.celrep.2019.02.080.
8
New perspectives on the mechanisms establishing the dorsal-ventral axis of the spinal cord.
Curr Top Dev Biol. 2019;132:417-450. doi: 10.1016/bs.ctdb.2018.12.010. Epub 2018 Dec 26.
9
Synergistic Activity of Floor-Plate- and Ventricular-Zone-Derived Netrin-1 in Spinal Cord Commissural Axon Guidance.
Neuron. 2019 Feb 20;101(4):625-634.e3. doi: 10.1016/j.neuron.2018.12.024. Epub 2019 Jan 17.
10
Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells.
Neuron. 2019 Feb 20;101(4):635-647.e4. doi: 10.1016/j.neuron.2018.12.025. Epub 2019 Jan 17.
Zotero 插件