Department of Neurobiology, University of California, Los Angeles, CA, United States; Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, CA, United States.
Department of Neurobiology, Stanford University, Palo Alto, CA, United States.
Curr Top Dev Biol. 2021;142:197-231. doi: 10.1016/bs.ctdb.2020.10.009. Epub 2020 Nov 19.
Commissural axons have been a key model system for identifying axon guidance signals in vertebrates. This review summarizes the current thinking about the molecular and cellular mechanisms that establish a specific commissural neural circuit: the dI1 neurons in the developing spinal cord. We assess the contribution of long- and short-range signaling while sequentially following the developmental timeline from the birth of dI1 neurons, to the extension of commissural axons first circumferentially and then contralaterally into the ventral funiculus.
连合轴突一直是鉴定脊椎动物轴突导向信号的重要模型系统。本综述总结了目前关于建立特定连合神经回路（发育中的脊髓中的 dI1 神经元）的分子和细胞机制的思考。我们评估了长程和短程信号的贡献，同时沿着从 dI1 神经元诞生开始的发育时间轴，依次追踪轴突的延伸，先是周向延伸，然后再向对侧延伸到腹索中。
