Reyes Christopher L, Ward Andrew, Yu Jodie, Chang Geoffrey
Department of Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, CB105, La Jolla, CA 92137, USA.
FEBS Lett. 2006 Feb 13;580(4):1042-8. doi: 10.1016/j.febslet.2005.11.033. Epub 2005 Dec 1.
ATP-binding cassette (ABC) transporters are integral membrane proteins that couple ATP hydrolysis to the transport of various molecules across cellular membranes. Found in both prokaryotes and eukaryotes, a sub-group of these transporters are involved in the efflux of hydrophobic drugs and lipids, causing anti-microbial and chemotherapeutic multidrug resistance. In this review, we examine recent structural and functional analysis of the ABC transporter MsbA and implications on the mechanism of multidrug efflux.
ATP结合盒（ABC）转运蛋白是整合膜蛋白，可将ATP水解与各种分子跨细胞膜的转运偶联起来。这些转运蛋白在原核生物和真核生物中均有发现，其中一个亚组参与疏水性药物和脂质的外排，导致抗微生物和化疗多药耐药性。在本综述中，我们研究了ABC转运蛋白MsbA的最新结构和功能分析及其对多药外排机制的影响。
