Department of Microbiology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Int J Mol Sci. 2024 Nov 14;25(22):12222. doi: 10.3390/ijms252212222.
is a major pathogen associated with various gastric diseases. Despite decades of research, the treatment of remains challenging. One of the primary mechanisms contributing to failures of therapies targeting this bacterium is genetic mutations in drug target sites, although the growing body of scientific data highlights that efflux pumps may also take part in this process. Efflux pumps are proteinaceous transporters actively expelling antimicrobial agents from the interior of the targeted cells and reducing the intracellular concentration of these compounds. Considering that efflux pumps contribute to both antimicrobial resistance and biofilm formation, an in-depth understanding of their properties may constitute a cornerstone in the development of novel therapeutics against . In line with this, the aim of the current review is to describe the multitude of efflux pumps produced by and present the data describing the involvement of these proteins in tolerance and/or resistance to various classes of antimicrobial substances.
是一种与各种胃病相关的主要病原体。尽管经过了几十年的研究，仍然难以治疗 。导致针对这种细菌的治疗方法失败的主要机制之一是药物靶点的基因突变，尽管越来越多的科学数据表明外排泵也可能参与这一过程。外排泵是一种蛋白质转运体，可将抗菌剂从靶细胞内部主动排出，降低这些化合物的细胞内浓度。考虑到外排泵既与抗菌药物耐药性有关，也与生物膜形成有关，深入了解其特性可能是开发针对 的新型治疗方法的基石。基于此，本综述的目的是描述 产生的多种外排泵，并介绍描述这些蛋白质在耐受和/或对抗各种类别的抗菌物质的作用的数据。
