Jursa Stanislav, Chovancová Jana, Petrík Ján, Loksa Juraj
Department of Toxic Organic Pollutants, Slovak Medical University, Limbová 12, SK-833 03 Bratislava, Slovak Republic.
Chemosphere. 2006 Jul;64(4):686-91. doi: 10.1016/j.chemosphere.2005.10.048. Epub 2005 Dec 9.
In the present study, non-ortho, mono-ortho and other ortho-substituted PCB congeners were analysed in individual blood serum samples taken from healthy adults (196 males and 119 females) in the polluted area of the Michalovce district and in the background area of the Stropkov/Svidnik districts in Eastern Slovakia by high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS). The samples from general population living in villages and towns of two regions were taken between August 2001 and February 2002 within the project of the EC's 5th Framework Programme (PCBRISK, ). The medians of dioxin-like PCBs (dl-PCBs)--expressed as TEQs on lipid basis--of all males (24.7 pg g(-1) lipid) and females (21.4 pg g(-1) lipid) were comparable, but there was a significant difference between both of the areas studied. In the district of Michalovce, the medians of males (47.3 pg g(-1) lipid) and females (41.1 pg g(-1) lipid) were 2.3 times higher than in the area of the Stropkov/Svidnik districts. The medians of total non-dioxin-like PCB concentration were 1,835 and 1,033 ng g(-1) lipid in males and females, respectively. The data show a trend toward higher concentrations of both dl- and non-dioxin-like PCBs in the older age groups. The substantial increase was observed for the 60+ age group. PCB-126 was the most abundant non-ortho congener. PCBs-118 and 156 were the predominant mono-ortho congeners. They were quantitated in all samples analysed. Congeners 153, 138(+163), 180 and 170(+190) were the main contributors to total non-dioxin-like PCB concentrations. Mean mutual ratio HexaCBs:HeptaCBs:OctaCBs in the non-dioxin-like group was 37:50:1. The results of this study represent the overall information about the congener distribution of dioxin-like and non-dioxin-like PCBs in human serum blood of adult Slovaks.
在本研究中，采用高分辨率气相色谱/高分辨率质谱法（HRGC/HRMS），对斯洛伐克东部米哈洛夫采区污染区域以及斯特罗普科夫/斯维德尼克区背景区域的健康成年人（196名男性和119名女性）个体血清样本中的非邻位、单邻位和其他邻位取代多氯联苯同系物进行了分析。2001年8月至2002年2月期间，在欧盟第五框架计划（PCBRISK）项目中采集了来自这两个地区村镇的普通人群样本。所有男性（24.7 pg g⁻¹脂质）和女性（21.4 pg g⁻¹脂质）的二噁英类多氯联苯（dl-PCBs）中位数（以脂质为基础表示为毒性当量）具有可比性，但所研究的两个区域之间存在显著差异。在米哈洛夫采区，男性（47.3 pg g⁻¹脂质）和女性（41.1 pg g⁻¹脂质）的中位数比斯特罗普科夫/斯维德尼克区高出2.3倍。男性和女性中非二噁英类多氯联苯总浓度的中位数分别为1835和1033 ng g⁻¹脂质。数据显示，在年龄较大的人群中，dl-PCBs和非二噁英类多氯联苯的浓度都有升高的趋势。在60岁及以上年龄组中观察到了大幅增加。PCB-126是含量最高的非邻位同系物。PCBs-118和156是主要的单邻位同系物。在所有分析样本中都对它们进行了定量。同系物153、138(+163)、180和170(+190)是总非二噁英类多氯联苯浓度的主要贡献者。非二噁英类组中六氯联苯：七氯联苯：八氯联苯的平均相互比例为37:50:1。本研究结果代表了斯洛伐克成年人人血清中二噁英类和非二噁英类多氯联苯同系物分布的总体信息。
