Ragavan Narasimhan, Grover Philip L, Balasubramanian Sabapathy P, Hindley Andrew C, Matanhelia Shyam S, Martin Francis L
Department of Biological Sciences, Lancaster University, Lancaster LA1 4YQ, UK.
Cancer Lett. 2006 Oct 8;242(1):88-94. doi: 10.1016/j.canlet.2005.10.038. Epub 2005 Dec 9.
Epidemiological studies suggest that environment plays an important role in the aetiology of cancer. Thus, if a cancer (e.g. prostate cancer (CaP)) arises in males, one could hypothesize that risk in co-habiting partners might be elevated. We conducted an observational-questionnaire study in NorthWest England evaluating the medical histories of CaP males and their female partners. Details regarding previous partners (>10y) were also sought. Self-filled questionnaires were obtained from 548 males, 81 of whom provided information on previous female partners (PFPs) and 448 current female partners (CFPs). Observed rates over a 30-y period (1971-2001) of common cancers (breast, colorectal or lung) in female partners and colorectal cancer in males were compared to the cumulative expected probability (estimated using crude incidence rates for England provided by the Office of National Statistics, UK) using a Chi-Square Goodness-of-Fit test. Colorectal cancers in males were similar to national estimates. Rates for breast, colorectal or lung cancer among CFPs and the total female cohort (CFPs plus PFPs) were also similar to estimates. However, observed rates for breast or lung cancers among PFPs were significantly (P< or =0.001) elevated. Our results suggest no evidence of elevated risk among female partners of CaP males.
流行病学研究表明，环境在癌症病因学中起着重要作用。因此，如果男性患某种癌症（如前列腺癌（CaP）），可以推测其同居伴侣患癌风险可能会升高。我们在英格兰西北部开展了一项观察性问卷调查研究，评估前列腺癌男性患者及其女性伴侣的病史。我们还询问了他们与前任伴侣（超过10年）的相关细节。我们从548名男性那里获得了自行填写的问卷，其中81人提供了关于前任女性伴侣（PFPs）的信息，448人提供了现任女性伴侣（CFPs）的信息。我们使用卡方拟合优度检验，将女性伴侣在30年期间（1971 - 2001年）患常见癌症（乳腺癌、结直肠癌或肺癌）的观察率以及男性患结直肠癌的观察率，与累积预期概率（使用英国国家统计局提供的英格兰粗发病率估算）进行了比较。男性结直肠癌的发病率与全国估算值相似。现任女性伴侣（CFPs）以及整个女性队列（CFPs加PFPs）中乳腺癌、结直肠癌或肺癌的发病率也与估算值相似。然而，前任女性伴侣（PFPs）中乳腺癌或肺癌的观察发病率显著升高（P≤0.001）。我们的结果表明，没有证据显示前列腺癌男性患者的女性伴侣患癌风险升高。
