Boada Fernando E, LaVerde George, Jungreis Charles, Nemoto Edwin, Tanase Costin, Hancu Ileana
Magnetic Resonance Research Center, Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Curr Top Dev Biol. 2005;70:77-101. doi: 10.1016/S0070-2153(05)70004-1.
This chapter demonstrates the use of sodium magnetic resonance imaging (MRI) as a noninvasive, in vivo means to assess metabolic changes that ensue from loss of cell ion homeostasis due to cell death in the brain. The chapter is organized in two sections. In the first section, the constraints imposed on the imaging methods by the nuclear magnetic resonance (NMR) properties of the sodium ion are discussed and strategies for avoiding their potential limitations are addressed. The second section illustrates the use of sodium MRI for monitoring focal brain ischemia in permanent and temporary primate models of endovascular middle cerebral artery occlusion.
本章展示了利用钠磁共振成像（MRI）作为一种非侵入性的体内手段，来评估因大脑细胞死亡导致细胞离子稳态丧失而引发的代谢变化。本章分为两个部分。在第一部分中，讨论了钠离子的核磁共振（NMR）特性对成像方法的限制，并阐述了避免其潜在局限性的策略。第二部分说明了在永久性和暂时性大脑中动脉闭塞的灵长类动物模型中，利用钠MRI监测局灶性脑缺血的情况。
