Khil Pavel P, Camerini-Otero R Daniel
Genetics and Biochemistry Branch, National Institutes of Health, Bethesda, MD 20892, USA.
Crit Rev Biochem Mol Biol. 2005 Nov-Dec;40(6):313-30. doi: 10.1080/10409230500356703.
Recent advances in genomic sequencing of multiple organisms have fostered significant advances in our understanding of the evolution of the sex chromosomes. The integration of this newly available sequence information with functional data has facilitated a considerable refinement of our conceptual framework of the forces driving this evolution. Here we address multiple functional constraints that were encountered in the evolution of the X chromosome and the impact that this evolutionary history has had on its modern behavior.
多种生物基因组测序的最新进展极大地推动了我们对性染色体进化的理解。将这些新获得的序列信息与功能数据相结合，有助于我们对驱动这种进化的力量的概念框架进行相当大的完善。在这里，我们探讨了X染色体进化过程中遇到的多种功能限制，以及这段进化历史对其现代行为的影响。
