Buchli Anita D, Schwab Martin E
Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology-Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Ann Med. 2005;37(8):556-67. doi: 10.1080/07853890500407520.
In the adult central nervous system (CNS) myelin and oligodendrocytes, Nogo-A exerts a growth inhibitory function leading to restricted axonal regeneration. After development of different anti-Nogo-A antibodies and other Nogo-A blocking reagents their application has recently been studied in various in vivo animal models of spinal cord injury and stroke. These studies show that intracerebral application of Nogo-A-inactivating reagents leads to enhanced regeneration and compensatory sprouting, structural reorganization or plasticity, and functional recovery as seen in different behavioural analyses.
在成体中枢神经系统（CNS）的髓磷脂和少突胶质细胞中，Nogo-A发挥生长抑制功能，导致轴突再生受限。在开发出不同的抗Nogo-A抗体和其他Nogo-A阻断试剂后，最近已在各种脊髓损伤和中风的体内动物模型中对它们的应用进行了研究。这些研究表明，脑内应用Nogo-A失活试剂可导致再生增强、代偿性发芽、结构重组或可塑性以及功能恢复，这在不同的行为分析中都有体现。
