Laboratoire de Physiologie et Physiopathologie, CNRS-UMR 7079, University Pierre et Marie Curie, 75005 Paris, France.
Biol Reprod. 2006 Mar;74(3):450-8. doi: 10.1095/biolreprod.105.047134. Epub 2005 Dec 7.
In mammals, the role played by germ cells in ovarian differentiation and folliculogenesis has been the focus of an increasing number of studies over the last decades. From these studies, it has emerged that bidirectional communication between germ cells and surrounding companion cells is required as soon as the initial assembly of follicles. Models of germ cell depletion that arise from both spontaneous and experimentally induced mutations as well as irradiation or chemical treatments have been helpful in deciphering the role played by germ cells from the onset of ovarian differentiation onward. This review reports current knowledge and proposes novel hypotheses that can be formulated from these models about the contribution of germ cells to ovarian differentiation and folliculogenesis. In particular, it promotes the idea that the influence of germ cells on companion somatic cells varies within both ovarian differentiation and folliculogenesis.
在哺乳动物中，生殖细胞在卵巢分化和卵泡发生中的作用一直是过去几十年越来越多研究的焦点。从这些研究中可以看出，一旦卵泡开始形成，生殖细胞与周围的伴细胞之间就需要双向通讯。自发和实验诱导突变、辐照或化学处理引起的生殖细胞耗竭模型，有助于从卵巢分化开始解析生殖细胞所起的作用。这篇综述报告了当前的知识，并从这些模型中提出了关于生殖细胞对卵巢分化和卵泡发生的贡献的新假设。特别是，它提出了这样一种观点，即生殖细胞对伴体细胞的影响在卵巢分化和卵泡发生中是不同的。
