Sakhalkar V S, Roberts K, Hawthorne L M, McCaskill D M, Veillon D M, Caldito G C, Cotelingam J D
Department of Pediatrics, Louisiana State University Health Science Center at Shreveport, Feist-Weiller Cancer Center, 1501 Kings Hwy., P.O. Box 33932, Shreveport, LA 71130-3932, USA.
Ann N Y Acad Sci. 2005;1054:495-9. doi: 10.1196/annals.1345.072.
Extended antigen (C, E, K) matching decreased the incidence of alloantibody (alloAB) and autoantibody (autoAB) formation, in addition to eliminating transfusion reactions in the multiply transfused sickle cell disease patients. AlloAB formation possibly transforms the immune system into a hyperactive state leading to further and earlier alloAB and autoAB formation. However, additional CEK matching results in marked overuse of Rh-negative packed red blood cell (pRBC) units, 30 minutes' extra time of a skilled technologist, and 153 dollars extra CEK reagent cost per unit to find CEK-matched pRBCs for every transfusion for these multiply transfused patients.
除了消除多次输血的镰状细胞病患者的输血反应外，扩展抗原（C、E、K）匹配还降低了同种抗体（alloAB）和自身抗体（autoAB）形成的发生率。同种抗体的形成可能会使免疫系统转变为一种过度活跃的状态，从而导致更多更早地形成同种抗体和自身抗体。然而，额外的CEK匹配会导致Rh阴性浓缩红细胞（pRBC）单位的过度使用、熟练技术人员额外30分钟的时间以及为这些多次输血的患者每次输血寻找CEK匹配的pRBC时每单位额外153美元的CEK试剂成本。
