Hmida S, Mojaat N, Maamar M, Bejaoui M, Mediouni M, Boukef K
Centre National de Transfusion Sanguine, Tunis, Tunisie.
Nouv Rev Fr Hematol (1978). 1994 Oct;36(5):363-6.
The present study was carried out to determine the evidence of alloimmunization against red blood cells in 364 patients transfused in our center over a period of 4 years (1990-1993). Among these patients, 127 were thalassemic and 182 had sickle cell disease (SCD). In 55 control patients, who received blood matched for the ABO, Rhesus and Kell antigen systems from the outset of transfusion, no immunization was detected. However, in the study group, who initially received blood matched only for ABH and Rh D antigens, the frequency of alloimmunization was 7.76% (24/309). Only one antibody was detected in 15 patients (62.5%) and two or more in 9 patients (37.5%). Alloimmunization concerned the Rhesus system in 58.82% of cases and the Kell system in 26.47%, while the frequency of immunization was significantly lower in patients of less than 5 years as compared to those in the age range 5-10 years (p < 0.001).
本研究旨在确定1990年至1993年期间在我们中心接受输血的364例患者中抗红细胞同种免疫的证据。这些患者中，127例为地中海贫血患者，182例患有镰状细胞病（SCD）。在55例对照患者中，从输血开始就接受了ABO、恒河猴和凯尔抗原系统匹配的血液，未检测到免疫反应。然而，在最初仅接受ABH和Rh D抗原匹配血液的研究组中，同种免疫的频率为7.76%（24/309）。15例患者（62.5%）仅检测到一种抗体，9例患者（37.5%）检测到两种或更多种抗体。同种免疫在58.82%的病例中涉及恒河猴系统，在26.47%的病例中涉及凯尔系统，与5至10岁年龄组的患者相比，5岁以下患者的免疫频率显著较低（p < 0.001）。
