O'Sullivan Brian P, Michelson Alan D
Department of Pediatrics, UMass Memorial Health Care, 55 Lake Avenue, North Worcester, MA 01655, USA.
Am J Respir Crit Care Med. 2006 Mar 1;173(5):483-90. doi: 10.1164/rccm.200508-1243PP. Epub 2005 Dec 9.
Platelets are an important, albeit generally underappreciated, component of the inflammatory cascade. Platelets are known to contribute to inflammation in atherosclerosis, stroke, and asthma. They produce a large number of proinflammatory lipid mediators and cytokines, and play a vital role in recruitment of leukocytes into inflamed tissue. We review the role of platelets in inflammation, how they assist in the recruitment of leukocytes into lung tissue in asthma, and evidence of their dysfunction in cystic fibrosis (CF). Platelet dysfunction in CF could contribute to pulmonary inflammation and tissue destruction. We hypothesize that platelet activation is important in CF lung disease and suggest research avenues that might help elucidate the role of activated platelets in CF.
血小板是炎症级联反应中的一个重要组成部分，尽管它通常未得到充分重视。已知血小板在动脉粥样硬化、中风和哮喘的炎症过程中发挥作用。它们产生大量促炎脂质介质和细胞因子，并在将白细胞募集到炎症组织中起着至关重要的作用。我们综述了血小板在炎症中的作用，它们如何在哮喘中协助白细胞募集到肺组织，以及它们在囊性纤维化（CF）中功能障碍的证据。CF中的血小板功能障碍可能导致肺部炎症和组织破坏。我们推测血小板激活在CF肺部疾病中很重要，并提出了可能有助于阐明活化血小板在CF中作用的研究途径。
